Sentences with phrase «subsets of patients with»

In concurrent studies, the team will examine the gene expression profile of subsets of patients with different clinical outcomes to provide further insight into why certain dogs have more aggressive B - CLL and to identify possible drug targetable pathways to improve the treatment for this cancer.

The Solution: Dr. Awan looked at subsets of patients with variety of the most common chronic joint and soft tissue conditions.

Not only does this suggest that the cause of Crohn's disease in these patients may be oxidative stress due to dysfunctional MDR1, but that for the subset of patients with this dysfunction, bile acid sequestrants may be an effective treatment.

The result is a genomically defined subset of patients with a clear likelihood of clinical improvement.

The finding might lead to new therapies for a subset of patients with glioblastoma, the most common and lethal form of brain cancer.

But Yale researchers have identified a subset of those patients with a rare genetic mutation who are living significantly longer than patients without the mutation.

Ambulatory systolic blood pressure — measured by a portable machine that patients wore for 24 hours — dropped significantly for all patients at six months, with a drop of 7.9 mmHg for all patients with blood pressure readings of 140 or higher — and the largest reductions, 9.2 mmHg, for the subset of patients with ambulatory systolic blood pressure of 160 or higher.

«We found that intensive doses of statins carry the potential for clearing up the lipid debris that can lead to vision impairment in a subset of patients with macular degeneration,» said Joan W. Miller, M.D., the Henry Willard Williams Professor and Chair of Ophthalmology at Harvard Medical School and Chief of Ophthalmology at Massachusetts Eye and Ear and Massachusetts General Hospital.

«This probably only explains a small subset of patients with pulmonary fibrosis,» he says.

The third paper in the issue of the Journal of Clinical Oncology describes an analysis of a very rare subset of patients with low - stage disease and amplification of the MYCN oncogene.

It is the first treatment targeting the underlying cause of CF in a subset of patients with a specific mutation.

A growing number of studies also suggest that HHV - 6 may play a role in a subset of patients with chronic conditions.

Only a subset of patients with neuropathies may respond well to opiates; 51 alternatively, higher - than - typical opiate dosing may be necessary for effective pain control in neuropathies, 52 thus raising serious concerns about sedation and drug dependence.

«It might have a role, but in a very, very small subset of patients,» Ismail said, «and I don't think we've identified that subset of patients with a really good randomized controlled trial.»

Not exact matches

Associate professor Mary - Ellen Taplin, of the Dana - Farber Cancer Institute, Boston, USA, will tell the 26th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiraterone.

If hypofractionated radiation with curative intent can reduce the treatment time for lung cancer patients by half with no greater toxicity, and with equivalent — if not better — tumor control and survival outcomes, this research could result in a change in the paradigm of how a large subset of locally advanced NSCLC patients are treated.»

The new findings build on prior research from the Dhodapkar lab demonstrating that patients with Gaucher disease, an inherited lipid storage disorder, have a significant increased risk for developing myeloma; and the discovery of a subset of lipid - reactive immune cells, called type II NKT - TFH, that promote the development of plasma cells.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

In addition to anti-tumor responses, immune checkpoint inhibitors have also been associated with long - term remission in a subset of patients, Gu said.

A clinical trial studying the use of Verapamil (a drug currently in use for cardiovascular disease and cluster headache) in alleviating chronic rhinosinusitis (CRS) with nasal polyps revealed significant improvement in the symptoms of this subset of patients.

He and his colleagues wanted to see whether the effect of these drugs was limited to the subset of depression patients with high cytokine levels, or if it helped all people diagnosed with depression.

After a median follow - up of 22 months, the team found that the drugs were safe and shrank tumors in a subset of patients, with an overall response rate of 27 percent, which included complete responses in two patients and partial responses in four patients.

In a matched cohort of 1,706 patients in each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subset.

«First - line immunotherapy treatment can improve survival for subset of lung cancer patients: Results of phase III global clinical trial show that 75 percent of stage IV lung cancer patients with both complex tumor mutations and PDL - 1 positive status respond to nivolumab.»

And the real reason the trial is being conducted with these previously released drugs is to test whether the new medication really is a lot riskier to everyone or just to a subset of patients.

In a randomized, phase 2 multi-center clinical study, led by Manisha Shah, MD of The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), investigators tested the effectiveness of the targeted therapy drug, dabrafenib (pronounced «da bRAF e nib» and marketed as Tafinlar), given alone compared with the same drug given in combination with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients with B - raf mutations.

When Dillon and colleagues used a global proteomics approach to compare all proteins in the blood from a subset of the patients, CRP emerged with the strongest association to postoperative delirium.

Some Academy members are PhDs who study HIV but can't prescribe medication, so survey results were analyzed for only the subset of members who can do so: mostly primary care providers, internal medicine, and infectious disease specialists who see a mix of patients, some with the virus and some without it.

The study suggests that attacking those subsets with targeted drugs may degrade the disease's ability to spread throughout the bone marrow of affected patients, the authors say.

To confirm that the missing mutations were important for generating an immune response, the researchers cultured a subset of the neoantigen protein fragments containing the tumor mutations with immune cells taken from three patients» blood samples.

«The results of our study could offer new treatment to this population of patients, identifying a subset of malignant pleural mesothelioma who expressed PD - L1 and could be treated with targeted therapies to PD - L1,» Cedres says.

People with severe resistant hypertension — high blood pressure not controlled with three classes of medications — are a very challenging subset of patients.

«We now have a better idea of how NSAID use may benefit a subset of patients diagnosed with colorectal cancer,» said Xinwei Hua, the study's first author and an epidemiologist at Fred Hutch.

«Further research will reveal whether these antibodies are the mark of a clinically relevant subset of patients and, if so, whether immunosuppressive therapies can effectively treat children with these debilitating illnesses.»

The study enrolled 100 patients with de novo coronary lesions 2.25 - 3.50 mm in diameter and length ≤ 27 mm in two 50 - patient cohorts for angiographic, intravascular ultrasound, and clinical assessment at nine or 24 months, with optical coherence tomography (OCT) performed in a subset of 30 patients at multiple time periods.

But that optimism, plus the availability of FDA - approved drugs with an HDAC inhibitory effect, has also prompted many families to find doctors who will prescribe these drugs, without knowing whether they work, or at what doses, or in which subset of patients.

The paper, «Perturbations in the lipid profile of individuals with newly diagnosed type 1 diabetes mellitus: lipidomics analysis of a Diabetes Antibody Standardization Program sample subset,» published in Clinical Biochemistry, described lipidomics (see sidebar) analyses of blood samples from patients recently diagnosed with type 1 diabetes mellitus (T1DM).

An expert panel has published guidelines for treatment of Pediatric Acute Onset Neuropsychiatric Syndrome (PANS) and a subset of patients diagnosed with PAN Disorder Associated with Streptococcal Infection (PANDAS).

Overall, despite the dramatic therapeutic advances made elsewhere in the melanoma field, the poor prognosis of patients with mucosal melanoma mandates continued emphasis on laboratory and clinical research efforts in this rare subset of disease.

[44] Two other phase II clinical trials evaluated the efficacy of imatinib in patients with melanoma — including mucosal melanomas — harboring KIT mutations and / or amplifications, with a subset of cases involving mucosal primaries, and both found a disease control rate of approximately 50 %.

Characterized as a biological subset of PTCL - NOS, patients with dysregulation of the histone modification machinery may be amenable to therapeutic intervention with HDAC inhibitors, given either alone or in combination with hypomethylating agents.

While PEC - Direct development could advance more rapidly and make a major impact for the subset of type 1 diabetes patients at highest risk, we view PEC - EnCap as holding the promise of a functional cure for all patients with type 1 diabetes as well as an important therapy for many patients with type 2 diabetes.»

However, subset analyses of phase III trials suggest that patients with EGFR mutation - positive NSCLCs do not benefit from immunotherapy compared with docetaxel.

MYH7 mutations were predominantly found in Ebstein anomaly associated with LVNC and may warrant genetic testing and family evaluation in this subset of patients.

Drug Labels FDA drug labels contain the name of the particular symptom, disease, or subset of patients within a disease that the drug is approved to treat, along with instructions for using the drug properly (including the dosage and what to do when a patient misses a dose), a description of any special instructions for taking the drug (such as with food or water), storage instructions, the symptoms of side effects to the drug, the names of any conditions or foods the patient should not have while using the medication, any warnings or precautions, any risk of drug tolerance or dependency, and a list of drug ingredients.

Modeling mRNA expression heterogeneity in tumors through bimodal profiles is a novel powerful approach with the potential to uncover therapeutic targets that benefit subsets of cancer patients.

«There might be a subset of COPD patients who might benefit from statin use who don't need a statin for cardiovascular reasons, but the heart and lungs are intertwined, and it's hard to tease out someone with COPD who doesn't have risk factors for cardiovascular disease,» Horovitz said.

In one recent trial, 9 a subset of patients resistant to antidepressant treatment and identified by serum markers of inflammation, most notably C - reactive protein > 3mg / L, were responsive to treatment with the TNF - alpha antagonist (anti-inflammatory) infliximab (Remicade).

A subset of patients was randomly assigned to booster sessions, where they were asked to follow up with their therapist every 2 months up to a year from initiating the program.

High levels of HHV - 6B DNA in the brain biopsies of refractory epilepsy patients suggest the virus may play a role in a subset of those with this condition.