Experience, however, soon showed in what way they were to become the most dangerous; that the insufficiency of the means provided for their removal gave them a freehold and irresponsibility in office; that their decisions, seeming to concern individual suitors only, pass silent and unheeded by the public
at large; that these decisions, nevertheless, become law by precedent, sapping, by little and little, the
foundations of the consti.tution, and working its change by construction, before any one has perceived that that invisible and helpless worm has been busily employed in consuming its
substance.
A better understanding of
substance conversions
at active centers is ultimately also the
foundation, for example, for industrial drug manufacturing.