Sentences with phrase «substantia nigra dopaminergic»

Large, age - related deletions in mtDNA are likely responsible for the systemic rise in oxidative stress with aging, and for localized but terrible pathologies of skeletal muscle and substantia nigra dopaminergic neurons in aging bodies.

Not exact matches

We also observe a significant loss of dopaminergic neurons in the substantia nigra pars compacta 60 days after infection.

The main finding in brains of people with PD is loss of dopaminergic neurons in the area of the brain known as the substantia nigra.

Here we show that the loss of dopaminergic neurons can be protected against by direct actions in the substantia nigra.

In most cases, there was no evidence of dopaminergic cell death in the substantia nigra, with the exception of one of the more recent studies that observed it in a subset of DJ - 1 − / − mice (Rousseaux et al., 2012).

We hypothesized that crossing DJ -1-deficient mice with Polg mutator mice in order to increase mtDNA damage in their substantia nigra would result in the degeneration of dopaminergic neurons.

Several mouse models of DJ - 1 deficiency have been developed, but they do not have dopaminergic neuron cell death in the substantia nigra pars compacta (SNpc).

''... it could be hypothesized that PD is, at least in part, a type of «segmental» aging, in which specific, localized, and accelerated aging mechanisms, which for reasons at present largely unknown, markedly affect dopaminergic (DA) neurons in the pars compacta region of the midbrain substantia nigra (SnPC).»