Not exact matches
The symptoms of Parkinson's —
which is characterized by stiffness and can lead to a loss of motor and speech function — are triggered by the progressive death of neurons in a midbrain region called the
substantia nigra that produce the neurotransmitter dopamine (implicated in the pleasure and reward systems as well as in the maintenance of proper movement control).
Even more surprisingly, the researchers observed that areas of the brain, the globus pallidus and the
substantia nigra,
which participate in the reward circuit (activated when we love something), were more involved in people who do not like cheese than in those who do.
Last year, the same researchers showed that the trigger came from cells in a structure in the embryonic brain called the floor plate,
which dopamine cells brush past while migrating to their eventual home in a part of the brain called the
substantia nigra.
This involves killing
substantia nigra neurons on one side of the brains of rats,
which then develop a movement imbalance that causes them to turn in circles, as well as exhibiting other symptoms.
Glutamate indirectly activates the
substantia nigra and ventral tegmental area,
which contain cells whose axons release dopamine in the hippocampus.
''... it could be hypothesized that PD is, at least in part, a type of «segmental» aging, in
which specific, localized, and accelerated aging mechanisms,
which for reasons at present largely unknown, markedly affect dopaminergic (DA) neurons in the pars compacta region of the midbrain
substantia nigra (SnPC).»