Sentences with phrase «substantial levels in»

Treatment with the vectors restored sperm production to substantial levels in all nine animals treated, without inducing any discernable side effects.

Not exact matches

While the most substantial way to increase your campaign's ROI still involves increasing your account's overall average keyword quality score (as quality score and cost per lead metrics are directly correlated), your level of success in AdWords is heavily reliant on whether or not you have first acquired all the proper ingredients to create an overall bigger pie for yourself.

In a study that looked at U.S. regions where at least 80 percent of workers commute, Goldman found uneven results: Improving labor markets and declines in mortgage delinquency, but not enough to translate to substantial retail spending gains on a national leveIn a study that looked at U.S. regions where at least 80 percent of workers commute, Goldman found uneven results: Improving labor markets and declines in mortgage delinquency, but not enough to translate to substantial retail spending gains on a national levein mortgage delinquency, but not enough to translate to substantial retail spending gains on a national level.

Beyond the requirements that liquidity and regulators impose on us, we will purchase currency - related securities only if they offer the possibility of unusual gain — either because a particular credit is mispriced, as can occur in periodic junk - bond debacles, or because rates rise to a level that offers the possibility of realizing substantial capital gains on high - grade bonds when rates fall.

So it's no surprise that most have begun to realize that without a substantial investment in technology tools to help manage daily business operations, it will be difficult for them to take their businesses to the next level.

Conclusion The substantial increase in e-cigarette use among US adult smokers was associated with a statistically significant increase in the smoking cessation rate at the population level.

The effect on Amazon has been equally significant: I detailed last year how the revelation of AWS» financial results was effectively a Facebook - level IPO, and subsequent earnings reports in which AWS has demonstrated the power of scale — increased revenue plus increased margins — have only solidified the fact that AWS will be a substantial driver of Amazon's revenue and (eventual!)

No analysis on how systematic wage arbitrage allowed by trade globalization between countries of very different income level within an exchange rate system allowing massive an persistent trade imbalances led to a massive opening up of compensation scales in developed countries, as well as substantial under - employment.

Of the 826 firms in CrunchBase that have substantial teams, women hold down 22 percent of the roles on the investment team at the associate, vice president and principal levels.

At the same time, the current level of the exchange rate represents a big shift in relative prices, which should provide substantial ongoing assistance for the export sector (and the import - competing sector).

The top - level meetings in the Great Hall of the People were followed by announcements of substantial investments in the country by China.

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

In determining the size of the requested increase in the authorized share pool, we considered the level of overhang and took into account the fact that a substantial portion of the current outstanding equity awards are held by our CEO and had been granted to him prior to our initial public offering in 2006 (the «IPO»In determining the size of the requested increase in the authorized share pool, we considered the level of overhang and took into account the fact that a substantial portion of the current outstanding equity awards are held by our CEO and had been granted to him prior to our initial public offering in 2006 (the «IPO»in the authorized share pool, we considered the level of overhang and took into account the fact that a substantial portion of the current outstanding equity awards are held by our CEO and had been granted to him prior to our initial public offering in 2006 (the «IPO»in 2006 (the «IPO»).

The proposed $ 36 - billion project would be the largest private - sector investment in Canadian history and is expected to bring substantial economic benefits, including up to $ 2.5 billion in annual tax revenue for all levels of government and nearly $ 3 billion in annual contributions to Canada's GDP.

In that respect it is entering a vacuum, since current price levels in Israeli drugstores allow it to offer many products at very substantial discounts by comparison with theIn that respect it is entering a vacuum, since current price levels in Israeli drugstores allow it to offer many products at very substantial discounts by comparison with thein Israeli drugstores allow it to offer many products at very substantial discounts by comparison with them.

In a nutshell, Check Point has been making substantial changes to its sales organization and strategy in the U.S. «The changes we have implemented in the field didn't bear fruits yet and as noted before it will take a few quarters to ramp up the level of productivity and results as we expect,» Payne said in the conference call this weeIn a nutshell, Check Point has been making substantial changes to its sales organization and strategy in the U.S. «The changes we have implemented in the field didn't bear fruits yet and as noted before it will take a few quarters to ramp up the level of productivity and results as we expect,» Payne said in the conference call this weein the U.S. «The changes we have implemented in the field didn't bear fruits yet and as noted before it will take a few quarters to ramp up the level of productivity and results as we expect,» Payne said in the conference call this weein the field didn't bear fruits yet and as noted before it will take a few quarters to ramp up the level of productivity and results as we expect,» Payne said in the conference call this weein the conference call this week.

Many analysts argue that total debt in China in fact exceeds TSF, and believe that the true debt level is closer to 250 % of GDP, and perhaps even more if we include the substantial number of corporate receivables that have surged in recent years.

The PRPA has already completed substantial pre-development work at the sites, improving access, in anticipation of private development spurred by a Request for Expressions of Interest (REI) that was issued late last year and, the port authority said, «garnered a high level of response from maritime industry, manufacturing, and energy companies.»

In my view, the most likely accompaniment to economic weakness would not be a decline in nominal rates, but somewhat accelerated inflation (meaning that real interest rates might very well fall to negative levels), and possibly substantial weakness in the U.S. dollaIn my view, the most likely accompaniment to economic weakness would not be a decline in nominal rates, but somewhat accelerated inflation (meaning that real interest rates might very well fall to negative levels), and possibly substantial weakness in the U.S. dollain nominal rates, but somewhat accelerated inflation (meaning that real interest rates might very well fall to negative levels), and possibly substantial weakness in the U.S. dollain the U.S. dollar.

Clearly, it would take quite a while to build up substantial profits when using such small amounts, but it is nice to have the option to buy in low when risk levels are high.

Although there is substantial uncertainty over the timing and size of expansions, the analysis suggests that new capacity coming on stream between mid 2004 and 2007 would imply an increase in overall production of around 28 per cent from the levels of 2003/04, corresponding to annual growth of about 9 per cent.

With interest rates still hovering near the lowest levels they've ever been in 5,000 + years of recorded human history, it's very difficult to achieve a significant investment return without taking on substantial risk.

New York Stock Exchange — May 20, 2016 After receiving overwhelming support for its compensation program in the wake of substantial structural and disclosure - related changes announced ahead of the Company's 2015 annual meeting, shareholders must now consider whether these structural features, however robust, can ultimately be expected to reign in compensation that is routinely granted at levels far exceeding peer levels.

The substantial cut to overall immigration levels in Division A has devastating economic and social impacts.

While IWG's shares performed quite strongly in the first quarter, we see substantial upside from current levels and the company remains a significant holding in the portfolio.

If you earn more than a certain level, known as the Social Security disability threshold, you're considered to be participating in a substantial gainful activity.

In particular, following a quarter when falling petrol prices reduced inflation, the higher level of petrol prices in the first month of the June quarter suggests that a substantial contribution to the CPI is possible, which could take CPI inflation close to 3 per cent in the year to the June quarteIn particular, following a quarter when falling petrol prices reduced inflation, the higher level of petrol prices in the first month of the June quarter suggests that a substantial contribution to the CPI is possible, which could take CPI inflation close to 3 per cent in the year to the June quartein the first month of the June quarter suggests that a substantial contribution to the CPI is possible, which could take CPI inflation close to 3 per cent in the year to the June quartein the year to the June quarter.

Although $ GLD is still in a downtrend (until it convincingly breaks out above the $ 128 to $ 130 level), there are now 3 great reasons to buy gold in anticipation of a substantial, intermediate to long - term rally and / or bullish trend reversal.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

In the late 1960s and early 1970s, there were substantial ecumenical contacts between Christian Scientists and mainstream Christians at various levels.

A substantial argument could be given for the proposition that music such as one finds in Mozart's last opera, La Clemenza di Tito, puts one, more directly and intimately than metaphysics can do, in intuitive contact with the kind of thing which reality on its higher levels is, and, on various levels, universally manifests.

In spite of these parameters, it should be noted that many of the sustaining - time programs were of high quality and dealt with substantial issues at a deeper level of analysis than was possible in programs forced to maintain ratingIn spite of these parameters, it should be noted that many of the sustaining - time programs were of high quality and dealt with substantial issues at a deeper level of analysis than was possible in programs forced to maintain ratingin programs forced to maintain ratings.

Though substantial numbers of blacks and whites were active in this church, one or the other race tended to dominate each particular level of Trinity's youth and adult programs.

«They receive a substantial increase in pay when they qualify and another year to qualify for level two,» Layman says.

In my post «McDonald's makes a substantial commitment to coffee sustainability» I provided an overview of 2013 levels of certified coffee and farmer capacity - building partnerships.

He questioned the view that we need not be concerned with heavy concentration, instead preferring «standard economic wisdom» that «mergers resulting in high levels of concentration in markets with substantial barriers to entry will usually reduce competition and cause harm to consumers and our economy.»

Even with small reformulations — to decrease levels of salt in certain products, for instance — the impact on population health can be substantial.

Background: Several fast food companies have made commitments to reduce the levels of salt in the foods they serve, but technical issues are often cited as a barrier to achieving substantial reductions.

CBS is also reporting that SDSU's violations could be Level 1 which,» seriously undermine or threaten the integrity of the NCAA collegiate model as set forth in the Constitution and bylaws, including any violation that provides or is intended to provide a substantial or extensive recruiting, competitive or other advantage, or a substantial or extensive impermissible benefit.»

the banks want something to secure against the loan like massive long term tickets sales (like us) or some high substantial level of growth in revenue in a few years time from the loan.

of course no team wants to lose but I can guarantee you that the reaction by the Chelski fans after today's results are nowhere near what would have occurred if we shit the bed on opening day... the difference is they have tasted EPL success on more than one occasion recently, they have won the Champions League and they have done it with 3 different managers in the last 12 years with a similar, if not smaller, wage bill than us... in comparison, we have been experiencing our own personal Groundhog Day with nothing to show for it but a few silvery trinkets that would barely wet the appetite of a world - class club... so it's time for Wenger to stop gloating over our week one escape act and make some substantial moves before this window closes or I fear that things will take a horrible turn when the inevitable happens... living on a knife's edge is no way to go through a full season of football and regardless of what side of the argument you fall on, you could feel high levels of toxicity in the air and that was friggin week one... I would much rather someone tried their best and failed, than took half - measures and hoped for the best

The tier one teams — ice hockey and basketball at Quinnipiac — get the most publicity, have the biggest market draw, and receive the most substantial funding, with descending levels of funding in tiers two and three.

i still believe that to make a substantial change to our chances of, say advancing beyond our usual level in CL, we'll need to sign a WC striker.

That he was unable to change anything substantial in the tactical approach is a stark indictment of his leadership and suitability for a job at the very highest level.

Woodward has undoubtedly done a good job around the world promoting and selling the United brand and bringing in substantial funds through sponsorships, but why didn't the Glazers just leave him doing that rather than give him a level of power that he obviously can't handle.

A recent, substantial, UK / US study, which controlled for mothers» depression, found high levels of emotional and behavioural problems in children (particularly boys) aged 3.5 years associated with earlier depression in their fathers (Ramchandani et al, 2005).

• A substantial, UK / US study, which controlled for mothers» depression and for fathers» education levels, found severe postnatal depression in fathers associated with high levels of emotional and behavioural problems in their children (particularly boys) at age 3.5 years (Ramchandani et al, 2005) and at age 7 (Ramchandani & Stein, 2008).

A substantial body of research now indicates that high levels of involvement by fathers in two parent families are associated with a range of desirable outcomes in children and young people, including: better peer relationships; fewer behaviour problems; lower criminality and substance abuse; higher educational / occupational mobility, relative to that of parents; capacity for empathy; non-traditional attitudes to earning and childcare; more satisfying adult sexual partnerships; and higher self - esteem and life - satisfaction (for reviews see Flouri 2005; Pleck and Masciadrelli 2004).

Studies show that household income for women and children is more likely to drop below the poverty level immediately following a divorce, 13 declining by as much as 50 percent and causing substantial reductions in earnings capability and long - term wealth.14 Compared with children in intact families, children of divorced parents:

The subsequent spanking coming their way may be even more epic this time, as allegations fly of a high - level conspiracy in the original phone - hacking investigations and substantial pay offs from News of the World hacks.