Sentences with phrase «substantial risk as»

Not exact matches

As a result, the January minutes included a carefully worded caveat: «Evaluation of the efficacy, costs and risks of asset purchases might well lead the committee to taper or end its purchases before it judged that a substantial improvement in the outlook for the labor market had occurred.»

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

As described under «Director Nominees for Election,» the Board believes that each of the current members of the Board is a highly qualified and dedicated individual who brings to the Board his or her own particular and substantial expertise and experience, including relevant regulatory, financial services, financial and accounting, legal, and / or risk management skills.

Options involve risks and are not suitable for all investors as the special risks inherent to options trading may expose investors to potentially rapid and substantial losses.

While I continue to believe that the dollar faces substantial risk of further erosion in its exchange value, as well as a near doubling of the CPI over the coming decade or so (both reflecting the massive increase in U.S. government liabilities in recent years), those prospects are not likely to emerge until risk - aversion about credit default materially abates.

Our long history has allowed us to build extensive databases of proprietary index, risk and ESG data, as well as accumulate valuable historical market data, which is difficult to replicate and provides us with a substantial competitive advantage.

It notes, for example, that about 55 % of the world's current oil output comes from countries Freedom House categorizes as «not free,» a substantial risk that makes America's resurgence in oil production all the more important.

Second, there is at least a significant risk that as the rest of the world struggles there will be substantial inflows of capital into the US leading to downward pressure on rates and upward pressure on the dollar, which in turn reduces demand for traded goods.

We believe that our pledging policy effectively mitigates the risk that forced sales of pledged shares could prompt a broader sell - off or further depress a declining stock price, while providing our officers and directors with reasonable flexibility to use their FedEx shares as collateral for loans for needed liquidity and encouraging them to retain substantial ownership of their shares.

It is only where either a) a money manager has a substantial amount of their own money invested in the same things as you or b) the money manager owns a substantial stake in their firm, so have a longer - term view in the success of the firm and its clients, that you can be confident that your money manager is really working for you, and not taking unneccessary risks.

Last week, Bank of America's (BOA) released their SEC annual report that also contained a mention of cryptocurrencies as a threat to their business, with the risk of competition described in very similar terms: «the widespread adoption of new technologies, including internet services, cryptocurrencies and payment systems, could require substantial expenditures to modify or adapt our existing products and services.»

Such risk, moreover, is exacerbated by the very fact that the products tend to attract issuers that have substantial debt and have previously found it difficult to gain access to traditional lending channels such as bank loans.

As usual, I don't place too much emphasis on this sort of forecast, but to the extent that I make any comments at all about the outlook for 2006, the bottom line is this: 1) we can't rule out modest potential for stock appreciation, which would require the maintenance or expansion of already high price / peak earnings multiples; 2) we also should recognize an uncomfortably large potential for market losses, particularly given that the current bull market has now outlived the median and average bull, yet at higher valuations than most bulls have achieved, a flat yield curve with rising interest rate pressures, an extended period of internal divergence as measured by breadth and other market action, and complacency at best and excessive bullishness at worst, as measured by various sentiment indicators; 3) there is a moderate but still not compelling risk of an oncoming recession, which would become more of a factor if we observe a substantial widening of credit spreads and weakness in the ISM Purchasing Managers Index in the months ahead, and; 4) there remains substantial potential for U.S. dollar weakness coupled with «unexpectedly» persistent inflation pressures, particularly if we do observe economic weaknesAs usual, I don't place too much emphasis on this sort of forecast, but to the extent that I make any comments at all about the outlook for 2006, the bottom line is this: 1) we can't rule out modest potential for stock appreciation, which would require the maintenance or expansion of already high price / peak earnings multiples; 2) we also should recognize an uncomfortably large potential for market losses, particularly given that the current bull market has now outlived the median and average bull, yet at higher valuations than most bulls have achieved, a flat yield curve with rising interest rate pressures, an extended period of internal divergence as measured by breadth and other market action, and complacency at best and excessive bullishness at worst, as measured by various sentiment indicators; 3) there is a moderate but still not compelling risk of an oncoming recession, which would become more of a factor if we observe a substantial widening of credit spreads and weakness in the ISM Purchasing Managers Index in the months ahead, and; 4) there remains substantial potential for U.S. dollar weakness coupled with «unexpectedly» persistent inflation pressures, particularly if we do observe economic weaknesas measured by breadth and other market action, and complacency at best and excessive bullishness at worst, as measured by various sentiment indicators; 3) there is a moderate but still not compelling risk of an oncoming recession, which would become more of a factor if we observe a substantial widening of credit spreads and weakness in the ISM Purchasing Managers Index in the months ahead, and; 4) there remains substantial potential for U.S. dollar weakness coupled with «unexpectedly» persistent inflation pressures, particularly if we do observe economic weaknesas measured by various sentiment indicators; 3) there is a moderate but still not compelling risk of an oncoming recession, which would become more of a factor if we observe a substantial widening of credit spreads and weakness in the ISM Purchasing Managers Index in the months ahead, and; 4) there remains substantial potential for U.S. dollar weakness coupled with «unexpectedly» persistent inflation pressures, particularly if we do observe economic weakness.

For further information click here Options involve risks and are not suitable for all investors as the special risks inherent to options trading may expose investors to potentially rapid and substantial losses.

But it's essential to contain ones exuberance as regional risk can easily entangle in higher US yields, but so far the push in treasury yields has not been intense enough to cause a substantial adverse shift in risk sentiment, but caution prevails as the move higher in US Bond yields could be far from over.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

• A substantial study in New Zealand identified father's smoking as a risk factor for breastfeeding cessation at four months postpartum, independently of mother's smoking and other factors (McLeod et al, 2002).

Many of the epidural side effects mentioned below are not improved with low - dose or walking epidurals, because women using these techniques may still receive a substantial total dose of local anesthetic, especially when continuous infusions and / or patient - controlled boluses (single large doses) are used.34 The addition of opiate drugs in epidurals or CSEs can create further risks for the mother, such as pruritus (itching) and respiratory depression (see below).

They may be aware of the greater risk for mood disorders such as depression and anxiety associated with sleep loss; the substantial impairment in cognitive abilities such as sustained attention, short - term memory, information processing, and school performance; or the increased risk for motor vehicle accidents that accompanies lack of sleep.

There is substantial evidence from round the world to show that sleeping your baby on their back (known as the supine position) at the beginning of every sleep or nap significantly reduces the risk of sudden infant death.

high risk of bias (e.g. numbers or reasons for missing data imbalanced across groups; «as treated» analysis done with substantial departure of intervention received from that assigned at randomisation);

In Japan, a system of lifetime employment in many big businesses, a tradition of employer provided benefits such as housing in many cases, and a wage system in those kinds of businesses where workers receive a substantial share of their annual income in the form of an annual bonus whose size can be used to buffer good and bad years for a company sharing risks and rewards with workers instead of limiting the risks and rewards to an investor class, have contributed to low levels of income inequality in the Japanese economy relative to comparably developed countries with comparable levels of government spending on welfare state type programs in other countries.

The Erie County Department of Senior Services (herein referred to as «Seniors») has completed a review of the Trump 2018 Budget Blueprint and concludes the following programs are to be cut or at risk of a loss of substantial funding:

It leaves out the very substantial contribution that 2 - 2.5 % annual growth would make to cutting the deficit, and indeed imposes spending cuts of such a magnitude as would significantly ratchet down growth potential and risk a double - dip recession.

«Participants on the very - high - fat diet also had substantial improvements in several important cardiometabolic risk factors, such as ectopic fat storage, blood pressure, blood lipids (triglycerides), insulin and blood sugar.»

Treatments such as behavioral therapies or continuous glucose - monitoring systems can prevent these events in many — but not all — people with this impaired awareness, leaving a substantial number of people at risk.

They define the condition as «a pattern of financial behavior that places an older adult at substantial risk for a considerable loss of resources such that dramatic changes in quality of life would result.»

«Furthermore, a substantial elevation in PM2.5 may also serve as a nudge that reminds or alerts people to avoid areas and activities where other people may share an infection with them, to not touch their face with dirty hands, to be vigilant about washing their hands when reasonably possible or prudent, and to engage in other preventive behaviors that are known to reduce infection risk.»

«Unfortunately, more research is still needed, as the current treatments have substantial risk of side effects, and few studies have been done on the long - term effects of these drugs.»

And, because stroke risk rises sharply after age 60, countries with large «boomer» populations, such as the United States, are on course for a substantial increase in stroke prevalence...

The 2009 «Banerjee Report», commissioned by the Department of Health as part of the NDS, examined the use of antipsychotics for people with dementia, concluding that the drugs had a «substantial clinical risk» associated with them and that their overuse «must not be allowed to continue.»

Development of low back pain in adolescents is a substantial risk factor for the possibility of low back pain as an adult.

In rich economies, such as Austria or the Netherlands, substantial investments in flood protection are best to both reduce flood risk and enable economic growth.

Use of oral contraceptives (usually referred to as «the pill»), even for just a few years, gives substantial long - term protection against endometrial (womb) cancer, and the longer the pill is used the greater the reduction in risk, according to a detailed re-analysis of all the available evidence, published in The Lancet Oncology journal.

Limiting clinical investigations to women who are at risk of transmitting a serious mtDNA disease, where the mutation's pathogenicity is undisputed, and the clinical presentation of the disease is predicted to be severe, as characterized by early mortality or substantial impairment of basic functions; and

-- The term «most vulnerable developing countries» means, as determined by the Administrator of USAID, developing countries that are at risk of substantial adverse impacts of climate change and have limited capacity to respond to such impacts, considering the approaches included in any international treaties and agreements.

Late last week, FDA worked with the United States Attorney to ask a court to seize the components of a product that involved the use of vaccinia virus vaccine as part of a purported treatment for cancer that FDA believes created the potential for substantial risks to patients.

AMP T2D focuses on type 2 diabetes genetics, seeking to use and supplement the substantial amount of human genetic data available from people with type 2 diabetes, or at risk of developing it, to identify and validate novel molecules and pathways as targets for therapeutic development.

It found substantial evidence of an association between cannabis use and the risk of motor vehicle crashes, as well as of lower birth weight after maternal use, more frequent chronic bronchitis episodes, and the development of schizophrenia or other psychoses.

«There's a really substantial amount of research that correlates more plant - based diets with decreased risk of chronic diseases [such as] heart disease, cancer and diabetes.»

It seems that when combined with diet and lifestyle changes, red yeast rice supplements can lower LDL, or bad cholesterol, levels by more than 20 % without a substantial risk of muscle pain (also known as myalgia), according to a study published Monday in the Annals of Internal Medicine.

«A shift to a dietary pattern higher in healthful plant - based foods, such as vegetables, fruits, whole grains, legumes, nuts, and seeds, and lower in animal - based foods, especially red and processed meats, can confer substantial health benefits in reducing risk of type 2 diabetes,» said Frank Hu, professor of nutrition and epidemiology at Harvard Chan School and senior author of the study.

Norwegian researchers found that in addition to not increasing study subjects» risk of heart disease, those on a diet high in fat exhibited «substantial improvements in several important cardiometabolic risk factors, such as ectopic fat storage, blood pressure, blood lipids (triglycerides), insulin and blood sugar.»

Whilst this technique is possible with lower body, use it cautiously as the injury risk and fatigue generated can be a lot more substantial than with the upper body

We know with confidence that long - term ketosis poses substantial risk for health complications because thousands of children have followed ketogenic diets over the years as a means of suppressing intractable grand mal seizures unresponsive to drugs and procedures, seizures that can lead to irreversible brain damage if not stopped.

Coupled with the substantial number of animal studies that show improved blood sugar regulation following strawberry intake, as well as the low GI value for strawberries and their provision of nutrients like folate, we expect to see future studies that document the benefits of strawberries for lowering risk of type 2 diabetes in humans, and also perhaps also for improved blood sugar regulation in persons already diagnosed with this condition.

From these studies, we know with confidence that long term ketosis may pose substantial risk for health complications due to the side effects experienced by the thousands of children who have followed ketogenic diets over the years as a means of suppressing seizures unresponsive to drugs and procedures.

Like eternal bachelors, many schools are sitting quietly, hoping that it will «never happen to them» but I believe there's a certain inevitability that, as time passes, the benefits of shacking up together (or perhaps more significantly, the risks of staying single) will become more substantial and tip more and more organisations this way.

Substantial progress has been made in the area of curriculum, where Risk «s recommendations could be fulfilled by rule changes, such as increasing requirements for graduation.

California: Mike Guerena, Director Educational Technology, Encinitas Union School District, CA Mike Guerena, described as «curious and committed» by colleagues, has led the nation in designing a complete suite of personalized learning programs for district students; believes in building the capacity of the educators with whom he works; models that risk - taking is essential for making substantial change; and looks for creative solutions to ensure equity for all students.