Sentences with phrase «substantial risk associated»

There is substantial risk associated with investing in any financial instrument.

Finally, right behind market fit and team problems, in terms of fatal startup failings, comes the substantial risks associated with strong competition (existing or emerging), which drives about 20 % of the new companies out of business.

Not exact matches

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

Second, financial logic embodied in the celebrated Modigliani Miller theorem and suggested by common sense holds that substantial reductions in leverage, if achieved, should be associated with reduced volatility, reduced sensitivity to shocks and lower risk premiums.

Blockchain technology can cut out the substantial intermediary costs, security risks, and record keeping infrastructure traditionally associated with such applications resulting in reduced cost, fewer time delays and less human error.

High Risk — Speculation (H / SPEC) High risk equities of companies with a short or unprofitable operating history, limited or less predictable revenues, very high risk associated with success, significant financial or legal issues, or a substantial risk / loss of princiRisk — Speculation (H / SPEC) High risk equities of companies with a short or unprofitable operating history, limited or less predictable revenues, very high risk associated with success, significant financial or legal issues, or a substantial risk / loss of princirisk equities of companies with a short or unprofitable operating history, limited or less predictable revenues, very high risk associated with success, significant financial or legal issues, or a substantial risk / loss of princirisk associated with success, significant financial or legal issues, or a substantial risk / loss of princirisk / loss of principal.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

American Pediatrican Association has stated «Use of a pacifier is associated with a substantial reduction in the risk of SIDS».

They may be aware of the greater risk for mood disorders such as depression and anxiety associated with sleep loss; the substantial impairment in cognitive abilities such as sustained attention, short - term memory, information processing, and school performance; or the increased risk for motor vehicle accidents that accompanies lack of sleep.

My rationale was that we know there are risks associated with artificial breastmilk and substantial benefits to human milk, particularly breastfeeding relationships.

What is often ignored by those who are opposed to bedsharing is that there is substantial evidence that children left in a crib in a room separate from their parents (the new «norm» in Western society) is associated with a large increased risk for SIDS, even when bedding and mattress and temperature are taken into account [5][6][7].

The 2009 «Banerjee Report», commissioned by the Department of Health as part of the NDS, examined the use of antipsychotics for people with dementia, concluding that the drugs had a «substantial clinical risk» associated with them and that their overuse «must not be allowed to continue.»

Even with all of this research, it hasn't been clear whether the health risks associated with being a night owl are substantial enough to make a measurable difference in people's lives.

Hypertension is a major risk factor for cardiovascular disease and is associated with substantial morbidity and mortality, estimated to account for 35 % of myocardial infarction and stroke, 49 % of heart failure, and 24 % of premature mortality (42).

«They provide important evidence to inactive individuals by showing that modest amounts of activity provide substantial benefit for postponing mortality, while reassuring very active individuals of no exercise - associated increase in mortality risk.»

Companies that are in similar businesses may be similarly affected by particular economic or market events; to the extent the Fund has substantial holdings within a particular sector, the risks associated with that sector increase.

The risk of loss in trading futures contracts or commodity options can be substantial, and therefore investors should understand the risks involved in taking leveraged positions and must assume responsibility for the risks associated with such investments and for their results.

The risk of loss in trading futures contracts, commodity options or forex can be substantial, and therefore investors should understand the risks involved in taking leveraged positions and must assume responsibility for the risks associated with such investments and for their results.

There are risks associated with investing in a public offering, including unproven management, and established companies that may have substantial debt.

Moreover, there are specific risks associated with trading spreads, including substantial commissions, because it involves at least twice the number of contracts as a long or short position and because spreads are almost invariably closed out prior to expiration.

The risk of loss in trading futures contracts, commodity options or forex can be substantial, and therefore investors should understand the risks involved in taking leveraged positions and must assume responsibility for the risks associated with such investments and for their -LSB-...]

The risk of loss in trading futures contracts, commodity options or forex can be substantial, and therefore investors should understand the risks involved in taking leveraged positions and must assume responsibility for the risks associated with such -LSB-...]

The risk of loss in trading futures contracts or options can be substantial, and therefore investors should understand the risks involved in taking leveraged positions and must assume responsibility for the risks associated with such investments and for their investment results.

Our debt management program offers substantial benefits without some of the costs and risks associated with debt settlement:

regarding the abovementioned «intelligence squared» debate (which i listened to on new york's npr station wnyc) regarding the extent and risks associated with agw, i'd just like to point out that by the end of the debate, there was a substantial increase in the audience who described themselves as skeptics.

... they caution that society should fully quantify direct and indirect GHG emissions associated with energy alternatives and associated consequences prior to making policy commitments that have long - term effects on global forests; for they ominously warn «there is a substantial risk of sacrificing forest integrity and sustainability for maintaining or even increasing energy production with no guarantee to mitigate climate change.»»

Although the most advanced theoretical climate models still leave uncertainty, particularly about the sign and magnitudes of the effects, on GHG feedbacks, of some low - and high - clouds, a consensus began to develop that threats of resulting increases in global temperature — and the very large risks associated with their possible consequences — deserved substantial increase in attention.

Then - president Derek Bok said it was out of a desire not to be associated with «companies engaged in significant sales of products that create a substantial and unjustified risk of harm to human health.»

Daniela is also a Certified Information Privacy Professional (CIPP), and has substantial experience identifying, evaluating, and managing risks associated with clients» privacy and cybersecurity issues.

Such contracts normally have a high degree of risk associated with them, could be substantial in value and have a range of different insurances, warranties and the like which also have to be taken account of and balanced in an appropriate manner.

Regulators face substantial challenges when evaluating the risks associated with cryptocurrencies.

Mitigated substantial financial risk by managing credit support arrangements associated with asset divestments

Excessive drinking in adolescence can cause substantial harm to individuals and is associated with future alcohol - related problems.1 — 3 Drinking in adolescence is particularly risky because it is much more likely to be heavy and episodic (binge).4, 5 Excessive drinking during adolescence, while the brain is still developing, can be a major cause of trauma, physical injuries, hospitalisation, prolonged disability and premature death.1 — 3, 6 Alcohol contributes substantially to motor vehicle collisions, homicides, suicide, assault, sexual risk - taking and many other problems in Canada and the USA.7 — 16

Given the substantial prevalence of adolescent depressive disorders, associated functional impairments, the risk of unhealthy behaviors, and life - long illness, it is vital that we develop, evaluate and disseminate preventative programs for adolescent depression, argues Tracy Gladstone, Ph.D..

«Given the substantial prevalence of adolescent depressive disorders, associated functional impairments, the risk of unhealthy behaviors, and life - long illness, it is vital that we develop, evaluate, and disseminate preventative programs for adolescent depression,» said Dr. Gladstone.

Anxiety disorders in preschool - age children represent an important clinical problem due to high prevalence, substantial impairment, persistence, and associated risk for later emotional problems.

Marriage is the central relationship for the majority of adults, and morbidity and mortality are reliably lower for married individuals than unmarried individuals across such diverse health threats as cancer, heart attacks, and surgery.1 - 4 Although loss of a spouse through death or divorce can provoke adverse mental and physical health changes,1,5 - 7 the simple presence of a spouse is not necessarily protective; a troubled marriage is itself a prime source of stress, while simultaneously limiting the partner's ability to seek support in other relationships.8 The impact of a turbulent marriage is substantial; for example, epidemiological data demonstrated that unhappy marriages were a potent risk factor for major depressive disorder, associated with a 25-fold increase relative to untroubled marriages.9 Similarly, other researchers found a 10-fold increase in risk for depressive symptoms associated with marital discord.10

A focus on early nutrition is important, as diet is a targetable risk factor; improving maternal and / or childhood diet may help lower the prevalence of early - onset conduct problems, thus lowering substantial societal and economic costs associated with childhood CP and related adjustment problems (Hsia and Belfer 2008).