Sentences with phrase «substantial risk factors»

Different cultural and ethnic backgrounds, as well as varying oral health and oral care habits, are to be regarded as substantial risk factors for the development of caries.

Inattentive driving is related to poor self - regulation, suggesting that attention deficits and high distractibility are substantial risk factors of unsafe driving practices among adolescents.

Texas homeowners also reported substantial risk factors outside the home that increased liability risks for providers.

North Carolina homeowners also fared well when it came to substantial risk factors outside the home.

Development of low back pain in adolescents is a substantial risk factor for the possibility of low back pain as an adult.

In the same cohort, CHD was a substantial risk factor for parental mental health problems in children and their mothers at all time points (12).

Not exact matches

As usual, I don't place too much emphasis on this sort of forecast, but to the extent that I make any comments at all about the outlook for 2006, the bottom line is this: 1) we can't rule out modest potential for stock appreciation, which would require the maintenance or expansion of already high price / peak earnings multiples; 2) we also should recognize an uncomfortably large potential for market losses, particularly given that the current bull market has now outlived the median and average bull, yet at higher valuations than most bulls have achieved, a flat yield curve with rising interest rate pressures, an extended period of internal divergence as measured by breadth and other market action, and complacency at best and excessive bullishness at worst, as measured by various sentiment indicators; 3) there is a moderate but still not compelling risk of an oncoming recession, which would become more of a factor if we observe a substantial widening of credit spreads and weakness in the ISM Purchasing Managers Index in the months ahead, and; 4) there remains substantial potential for U.S. dollar weakness coupled with «unexpectedly» persistent inflation pressures, particularly if we do observe economic weakness.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange CommFactors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

Public health emphasis on reducing saturated fat consumption without considering the replacement nutrient or, more importantly, the many other food - based risk factors for cardiometabolic disease is unlikely to produce substantial intended benefits.

• A substantial study in New Zealand identified father's smoking as a risk factor for breastfeeding cessation at four months postpartum, independently of mother's smoking and other factors (McLeod et al, 2002).

«Participants on the very - high - fat diet also had substantial improvements in several important cardiometabolic risk factors, such as ectopic fat storage, blood pressure, blood lipids (triglycerides), insulin and blood sugar.»

These are known risk factors for substantial alcohol use.

These new findings, along with other recent studies, suggest that the risk for congenital heart defects in Down syndrome can come from several genes and environmental factors, in addition to the substantial risk from the extra chromosome 21.

«Obesity is a substantial stroke risk factor for all ages and even more alarming for young adults.»

Sun exposure is the primary risk factor for BCC, but genetic predisposition also plays a substantial role.

Analysis of four SNPs, in tandem with genetic risk factors detected by the deCODE ProstateCancer ™ test, yields substantial improvement in efficacy of PSA screening Reykjavik, ICELAND, 15 December 2010 — Scientists from deCODE genetics and academic colleagues from...

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution.

Hypertension is a major risk factor for cardiovascular disease and is associated with substantial morbidity and mortality, estimated to account for 35 % of myocardial infarction and stroke, 49 % of heart failure, and 24 % of premature mortality (42).

Norwegian researchers found that in addition to not increasing study subjects» risk of heart disease, those on a diet high in fat exhibited «substantial improvements in several important cardiometabolic risk factors, such as ectopic fat storage, blood pressure, blood lipids (triglycerides), insulin and blood sugar.»

We now have two well - conducted RCTs examining events (not just risk factors) demonstrating the substantial benefits of this dietary pattern.

It said, in part, «A substantial body of scientific evidence identifies important developmental, familial, and social risk factors for violence.

Since a substantial part of my practice concerns the prevention of potential international child abduction, it is often of great importance to provide courts with a useful source of reliable evidence concerning such risk factors.

The court applied Tinker as interpreted in Wisniewski to identify 3 factors that suggested the postings foreseeably created a risk of substantial disturbance:

Notwithstanding these gender - specific risk and protective factors, in most cases, the same factors — ADHD, negative temperament, impulsivity, compromised intelligence — predict antisocial behavior in both males and females, as suggested by the substantial overlap shown in figure 4.99 Although some analysts have argued the need to concentrate on the commonalities in predictors of male and female offending, it is also important to note the areas in which risk factors differ by gender.100 Even if the differences between male and female offenders are confined to only a few key areas, the differences in these areas — for example, sensitivity to victimization, timing of onset of persistent offending, prevalence of mental health problems — can be substantial and can profoundly influence the effectiveness of risk assessments and treatment programs.

For example, substantial evidence exists that families most plagued by domestic violence are least likely to respond to home - visiting support.23 Other factors that hamper success of home visiting include limited family resources, family mental illness, and families not motivated to participate in the programs.24 Thus, the very risk factors that make children vulnerable interfere with the effectiveness of the programs that are designed to help them.

It said, in part, «A substantial body of scientific evidence identifies important developmental, familial, and social risk factors for violence.

There is a substantial and growing body of evidence concerning the important role that familial risk factors play in facilitating young children's entry and progression along the «early - starter» pathway of conduct problems.

Marriage is the central relationship for the majority of adults, and morbidity and mortality are reliably lower for married individuals than unmarried individuals across such diverse health threats as cancer, heart attacks, and surgery.1 - 4 Although loss of a spouse through death or divorce can provoke adverse mental and physical health changes,1,5 - 7 the simple presence of a spouse is not necessarily protective; a troubled marriage is itself a prime source of stress, while simultaneously limiting the partner's ability to seek support in other relationships.8 The impact of a turbulent marriage is substantial; for example, epidemiological data demonstrated that unhappy marriages were a potent risk factor for major depressive disorder, associated with a 25-fold increase relative to untroubled marriages.9 Similarly, other researchers found a 10-fold increase in risk for depressive symptoms associated with marital discord.10

Substantial attention has been paid to understanding the risk factors for AD and their implications in the atopic march toward allergic rhinitis and ultimately asthma [2, 6 — 11].

A focus on early nutrition is important, as diet is a targetable risk factor; improving maternal and / or childhood diet may help lower the prevalence of early - onset conduct problems, thus lowering substantial societal and economic costs associated with childhood CP and related adjustment problems (Hsia and Belfer 2008).

The understanding that adolescence is a developmental period that involves substantial risk for maladaptive behavioral outcomes (e.g., delinquency, substance abuse; Hawkins et al. 1992), and that family factors are consistent predictors of adolescent functioning (Kumpfer et al. 1998), has prompted extensive efforts to prevent risk for negative outcomes (e.g., association with antisocial peers) and promote positive aspects of family functioning through skills - building (e.g., teaching effective parenting behaviors).

Environmental risk factors for ADHD have shown to have more substantial effect sizes than genetic factors [27], and may have more immediate relevance for clinical treatment.