Sentences with phrase «substantial risks on»

K - 9 teams face substantial risks on a daily basis.

Not exact matches

Vaping is addictive... or not... depending on who's doing it: «Among youth» (that's anybody who would never be caught dead using the word «youth»), «there is substantial evidence that e-cigarette use increases the risk of transitioning to smoking conventional cigarettes.»

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

Second, there is at least a significant risk that as the rest of the world struggles there will be substantial inflows of capital into the US leading to downward pressure on rates and upward pressure on the dollar, which in turn reduces demand for traded goods.

Sentiment indicators may have picked up across much of the world, but large parts of the global economy continue to rely on substantial monetary stimulus, and political risk remains a significant concern for investors, in both Europe and the United States.

As usual, I don't place too much emphasis on this sort of forecast, but to the extent that I make any comments at all about the outlook for 2006, the bottom line is this: 1) we can't rule out modest potential for stock appreciation, which would require the maintenance or expansion of already high price / peak earnings multiples; 2) we also should recognize an uncomfortably large potential for market losses, particularly given that the current bull market has now outlived the median and average bull, yet at higher valuations than most bulls have achieved, a flat yield curve with rising interest rate pressures, an extended period of internal divergence as measured by breadth and other market action, and complacency at best and excessive bullishness at worst, as measured by various sentiment indicators; 3) there is a moderate but still not compelling risk of an oncoming recession, which would become more of a factor if we observe a substantial widening of credit spreads and weakness in the ISM Purchasing Managers Index in the months ahead, and; 4) there remains substantial potential for U.S. dollar weakness coupled with «unexpectedly» persistent inflation pressures, particularly if we do observe economic weakness.

With interest rates still hovering near the lowest levels they've ever been in 5,000 + years of recorded human history, it's very difficult to achieve a significant investment return without taking on substantial risk.

If you listen to the tenor of investment strategists here, the basic message sounds a lot like what we heard in the late 1990's: stocks may not be priced to deliver strong returns on a sustained basis, and there are substantial risks in the longer - term picture, but for now, things seem to be going well and so there's no need to be defensive just yet.

Investors may be exposed to substantial risks and significant financial losses in trading cryptocurrency futures contracts and other cryptocurrency - related investment products (eg options, swaps and contracts for differences), especially on unregulated exchanges.

«A short volatility risk derives small incremental gains on the assumption of stability in exchange for a substantial loss in the event of change.

Although the turnaround in the stock's fortunes may only prove to be temporary, few short sellers can afford to risk runaway losses on their short positions and may prefer to close them out even if it means taking a substantial loss.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

It is customary and even ethically mandatory that experimentation that carries with it a substantial degree of risk to human subjects first be tested in an animal laboratory or, at the very least, on a computer model.

Public health emphasis on reducing saturated fat consumption without considering the replacement nutrient or, more importantly, the many other food - based risk factors for cardiometabolic disease is unlikely to produce substantial intended benefits.

There is substantial evidence from round the world to show that sleeping your baby on their back (known as the supine position) at the beginning of every sleep or nap significantly reduces the risk of sudden infant death.

Arguments in favor of circumcision benefits indicate they outweigh the risks, have no substantial effects on sexual function, they are low in complications when done properly by an experienced person, and is best performed in the neonatal period of life.

In Japan, a system of lifetime employment in many big businesses, a tradition of employer provided benefits such as housing in many cases, and a wage system in those kinds of businesses where workers receive a substantial share of their annual income in the form of an annual bonus whose size can be used to buffer good and bad years for a company sharing risks and rewards with workers instead of limiting the risks and rewards to an investor class, have contributed to low levels of income inequality in the Japanese economy relative to comparably developed countries with comparable levels of government spending on welfare state type programs in other countries.

Cuomo called the increased costs a «substantial burden» on taxpayers and could risk an increase in property taxes.

«Participants on the very - high - fat diet also had substantial improvements in several important cardiometabolic risk factors, such as ectopic fat storage, blood pressure, blood lipids (triglycerides), insulin and blood sugar.»

The piece based its recommendation on a meta - analysis of 27 clinical trials published in the same issue that concluded statins significantly reduce the risk of heart attacks and other cardiovascular events in healthy people without posing substantial risks.

The Lariat device received FDA 510 (k) class II (intermediate risk) clearance for soft tissue approximation in June 2006 based on stated «substantial equivalence» with other devices used to place sutures during laparoscopic surgeries or vein harvesting.

«Unfortunately, more research is still needed, as the current treatments have substantial risk of side effects, and few studies have been done on the long - term effects of these drugs.»

And, because stroke risk rises sharply after age 60, countries with large «boomer» populations, such as the United States, are on course for a substantial increase in stroke prevalence...

«Overall, climate change is projected to have substantial adverse impacts on future mortality, even considering only a subset of the expected health effects,» the agency said in its latest «Quantitative Risk Assessment of the Effects of Climate Change on Selected Causes of Death.»

Peters co-authored a paper published last year warning that staking the future only on negative emissions technologies presents a «moral hazard» because they're unproven, there is a substantial risk that the technology can't be scaled up, and it may allow policymakers to think that weaning humanity away from fossil fuels is not urgent.

AMP T2D focuses on type 2 diabetes genetics, seeking to use and supplement the substantial amount of human genetic data available from people with type 2 diabetes, or at risk of developing it, to identify and validate novel molecules and pathways as targets for therapeutic development.

«Those who have argued for the postponement of the Rio Olympics due to the risk posed by the ongoing Zika virus epidemic base their argument on two principal assumptions: 1) that the half a million visitors to Brazil will generate a substantial increase in exported Zika infections, and 2) that some of these exports will seed outbreaks in other parts of the world.

The future of astronomy in space will be at substantial risk if it must depend on the successful deployment of only a few missions per decade.

High - Risk Series: Progress on Many High - Risk Areas, While Substantial Efforts Needed on Others.

The findings «highlight the urgency of educating the public, policymakers and health care professionals about high - risk drinking and alcohol use disorder, destigmatizing these conditions, and encouraging those who can not reduce their alcohol consumption on their own — despite substantial harm to themselves and others — to seek treatment,» Grant and her colleagues concluded.

While keeping a detailed food diary might seem like a time - consuming proposition, it's one that can have a substantial impact on your health, especially if you want to lose weight and minimize obesity risks.

We suspect that the substantial protein content of cruciferous vegetables may contribute to their risk - lowering impact on certain cancers, partially due to their support of detoxification.

Norwegian researchers found that in addition to not increasing study subjects» risk of heart disease, those on a diet high in fat exhibited «substantial improvements in several important cardiometabolic risk factors, such as ectopic fat storage, blood pressure, blood lipids (triglycerides), insulin and blood sugar.»

While there isn't sufficient evidence of such claims about juice and its effect on our health, there is a substantial link between eating a plant - based diet and a reduced risk for cancer.

There's always going to be a substantial amount of risk built into dating; you have to be willing to put your neck on the line and potentially face up to being rejected.

However Rigby says that while 10 primary schools reported doing a «substantial amount» or «great deal» of classroom work on reducing the risk of cyber bullying, seven reported they did «little or none».

The results are consistent with other studies that show a substantial return (up to 50 percent of a standard deviation on standardized achievement tests) to achievement from observed classroom quality, with greater effects often accruing to children with higher levels of risk and disadvantage.

Nevertheless, recent studies have begun to question whether incidental instruction through book reading may be substantial enough to significantly boost children's oral vocabulary development.19 Several meta - analyses, for example, have reported only small to moderate effects of book reading on vocabulary development.20 One group of researchers examined the added benefits of dialogic reading, an interactive reading strategy, on children's vocabulary growth and reported only modest gains for 2 - to 3 - year - olds.21 Further, these effects were reduced to negligible levels when children were 4 to 5 years old or when they were at risk for language and literacy impairments.

Revises current law regarding refusal of entry to or ejection from a school to allow a school administrator, school resource office or school district peace officer to refuse to allow a person on property or to eject a person if the person refuses to leave on request and to implement such a ban for up to two years, if the person poses a substantial risk of harm to another person or behaves in a manner inappropriate for a school setting after being warned.

Gov. Brown Urges UCLA Students to Support Prop. 30 Gov. Jerry Brown brought his campaign for the Proposition 30 tax measure to UCLA on Tuesday, urging students at a rally there to vote for it or risk facing a substantial tuition increase.

It is not recommended to buy any vehicle that has the check engine light on, unless you have negotiated a substantial discount to cover the risk.

All the expenses of publishing now fall solely on the writer, creating a substantial personal financial risk.

But refinancing can mean substantial savings on your monthly payments, an overall cost reduction or even a risk reduction.

Exchange rate risk: Changes in the exchange rate of different currencies may have a substantial influence on the performance of an investment.

Since its inception, the portfolio added a substantial amount of value on a risk - adjusted basis.

Our products are specifically designed to cover final expenses and offer additional protection for risks such as loss of income, mortgage cancellation, education expenses, and debt repayment — all which can have a substantial financial impact on those you love.

Trading Futures, Options on Futures, and retail off - exchange foreign currency transactions involves substantial risk of loss and is not suitable for all investors.

Our risk assessment for JNJ reflects that its products are largely immune from economic cycles, that it does not rely on any single product category or customer for sustained growth and that it enjoys competitive advantages owing to its substantial financial resources, business scale and global sales capabilities.

While there is substantial value on the balance sheet relative to the stock price, the risk is that the company continues to trade and destroys that remaining value.

Takeaways: (1) The fund will focus on larger cap names both because they offer substantial liquidity and they have the lowest degree of «existential risk.»