Substitution therapy is a treatment method where one drug is replaced with another drug, usually to help reduce the harmful effects or addiction of the first drug.
Full definition
The problem with
drug substitution therapy is that it's expensive and requires daily trips to a clinic to receive the replacement drug.
The CO-STAR (Hepatitis C Patients on
Opioid Substitution Therapy Antiviral Response) trial sought to evaluate the efficacy and safety of elbasvir - grazoprevir for injection drug users.
Another strategy being looked at is using THC itself as kind
of substitution therapy, however Crippa points out this still leaves people addicted to THC.
Eighty - one (94 percent) of the mothers were receiving opioid
substitution therapy from the first trimester, with 17 (20 percent) relapsing into illicit drug use during the third trimester.
Although current prevention strategies, which are based on needle and syringe programmes and
opiate substitution therapy, can avert HCV infections and have reduced its prevalence in some cities from the very high levels that occurred in the 1980s, these interventions are unlikely alone to achieve further substantial reductions.
The letter raises urgent concerns about woefully inadequate resources and the abrupt and inhumane discontinuation of medication for patients who do receive
Opioid Substitution Therapy.
Janda said a heroin vaccine has many advantages over
drug substitution therapies — fewer side effects, no dependence on other opioids, lower overdose risk — but the biggest advantage may be the cost.
The three regions worldwide with the highest populations of people who inject drugs, east and south - east Asia, Eastern Europe and North America, all had poor provision of needle syringe programs and opioid
substitution therapy.
Yet despite evidence that needle and syringe programs (NSP) and opioid
substitution therapy (OST) reduce HIV and HCV infections, they are still not being implemented in many places, and few people can access them in many countries, the authors found.
Just over half (52 per cent) of the countries with evidence of injecting drug use had needle syringe programs and medical treatment to encourage reductions in injecting — opioid
substitution therapy — was available in less than half of all countries identified (48 per cent).
For people,
substitution therapies, which include slow acting opioids (methadone), opioids that produce a partial biological response (buprenorphine) or antagonists that block the opioid receptor (naloxone), are the only available treatments for opioid addiction are often leading to high rates of relapse.
«Most licensed treatments are
substitution therapies «such as methadone in the case of heroin addiction «so they maintain the addicted state, but more safely,» says Dalley.