Further, the production of acetoacyl CoA,
a substrate of ketone body formation, can occur only in the liver and thus does not apply to skeletal muscle metabolism.
Not exact matches
Emerging research (http://www.healthy-eating-politics.com/alzheimers-disease.html, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995232/) suggests a mix
of glucose and
ketone bodies often approaching and even exceeding 50 % as
ketones may be superior to a fuel
substrate made up
of mostly or entirely glucose.
Ketones provided the energy
substrate for our brains and
bodies when glucose wasn't available, such as in times
of famine which was a common occurrence for our early ancestors.
Muscles and other tissues progressively switch energy source from glucose to free fatty acids which are converted to
ketone bodies (acetoacetate and b - hydroxybutyrate); these become the primary energy
substrate for brain and other metabolically active tissues in the absence
of adequate glucose supply.
The physiological ketosis
of starvation makes sound evolutionary sense, as
ketone bodies have several thermodynamic advantages over other nutritional
substrates, in addition to their actions to conserve protein and glucose stores.