Sentences with word «subthalamic»

Furthermore, impaired subthalamic activity was caused by anomalous receptor signaling, leading to defective energy metabolism and accumulation of damaging oxidants.

Chorea, a loss of motor control that is characteristic of HD physical symptoms, is thought to reflect a dysfunction of the indirect pathway (IP) drive arising from a deficit of striatal output to globus pallidus (GP), which in turn innervates subthalamic nucleus (STN).

Subthalamic Level: All the Swag (shirt, coffee mug), your very own RoboRoach, AND a SpikerBox with RoboRoach recording leads to listen to antenna neural spikes!

Evaluation of MP - 10, a PDE10 inhibitor, on BACHD transgenic rats using dual recording of single units in Globus Pallidus and Subthalamic nucleus S. ZHONG, G. TOMBAUGH, L. MRZLJAK, V. BEAUMONT, C. SCHMIDT, M. ZALESKA, C. CHANG, A. GHAVAMI... Abstract / Posters

The experiment called into question the leading theory of how the technology works — activation of an area called the subthalamic nucleus.

Instead the electrodes appear to exert their effects on nerve fibers that reach the subthalamic nucleus from the motor cortex and perhaps other areas.

For example, DBS of the subthalamic nucleus (STN) is effective for alleviating sleep problems and fatigue associated with PD, producing noticeable long - term improvements in sleep efficiency and the quality and duration of continuous sleep.

«We wanted to address this by measuring the exact location and timing of electrical activity in the subthalamic nucleus and comparing the results with behavioural data collected while a decision - making task is being performed.»

The fundamental trade - off between speed and accuracy in decision making has been studied for more than a century, with a number of studies suggesting that the subthalamic nucleus region of the brain plays a key role.

«We measured the electrical activity of groups of nerve cells within the subthalamic nucleus in patients with Parkinson's disease, who had recently been treated with deep brain stimulation.

«The origin was initially traced to the substantial reduction in motor symptoms, overlooking the role of the brain stimulation area — the subthalamic nucleus — in the reward system.

Using mice genetically engineered to carry the Huntington's disease gene, scientists discovered the electrical activity of the subthalamic nucleus was lost.

The authors also found abnormalities in the subthalamic nucleus occur earlier than in other brain regions, and that subthalamic nucleus nerve cells progressively degenerate as the mice age, mirroring the human pathology of Huntington's disease.

People who have suffered damage to the subthalamic nucleus exhibit excessive movement and impulsive behavior, similar to patients with Huntington's disease.»

Northwestern Medicine scientists identified a link between Huntington's disease and dysfunction of the subthalamic nucleus, a component of the basal ganglia, a group of brain structures critical for movement and impulse control.

«While research into Huntington's disease has focused on other parts of the basal ganglia, the subthalamic nucleus has been largely overlooked,» said Bevan.

«This is surprising because patients with Huntington's disease have fewer nerve cells in the subthalamic nucleus.

«Our findings suggest early problems in the subthalamic nucleus not only contribute to the symptoms of Huntington's disease, but are also likely to impair the processing capacity and health of other brain structures, more traditionally associated with the disease,» Bevan said.

Also beginning in the 1980s, they showed in animals and people that surgically implanting in the brain a device that stimulates the subthalamic nucleus can alleviate tremors and other symptoms of people with Parkinson's disease.

They found that individual neurons in the subthalamic nucleus (a common target for surgical attempts to relieve Parkinson's symptoms) began to fire less often when the saline was given, and with fewer «bursts» of firing — another feature associated with Parkinson's.

While Htt null KO mice do not survive to birth (Duyao et al., 1995; Nasir et al., 1995; Zeitlin et al., 1995), mice expressing a 50 % reduction of endogenous htt levels reveal cognitive and motor deficits (Nasir et al., 1995) and significant decreases in the number of neurons in globus pallidus and subthalamic nucleus (O'Kusky et al., 1999).

Evaluation of MP - 10, a PDE10 inhibitor, on BACHD transgenic rats using dual recording of single units in Globus Pallidus and Subthalamic nucleus.

However, we found that dopamine neurons projecting to the posterior striatum were outliers, receiving relatively few inputs from the ventral striatum and instead receiving more inputs from the globus pallidus, subthalamic nucleus, and zona incerta.

The 2014 Lasker ~ DeBakey Clinical Medical Research Award honors two scientists who developed deep brain stimulation of the subthalamic nucleus, a surgical technique that reduces tremors and restores motor function in patients with advanced Parkinson's disease.

These findings strongly supported the hypothesis that hyperactivity in the subthalamic nucleus underlies PD symptoms.

I have Parkinson's Disease Plus with an Subthalamic Nucleus Deep Brain Stimulator, embedded under my right breast to slow down the progression of my Parkinson's Disease Plus.