Sentences with phrase «subunits lead»

Deficiency of either subunit leads to severe immunodeficiency.

Rotation of the central stalk against the surrounding alpha (3) beta (3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Not exact matches

«The applications for this thing are kind of endless,» says chemist Christopher Cahill of George Washington University in Washington, D.C. Choosing the right linker molecule between subunits could lead to even roomier crystals or give them other useful chemical properties, he says.

These results led to three conclusions about the chemical nature of ion binding sites in the conduction pathway: The channel contains two identical titratable sites, even though there are more than two (probably four) identical subunits; the sites are formed by glutamate residues that have a pKa (where K (a) is the acid constant) of 7.6; and protonation of one site does not perturb the pKa of the other.

Analysis of crosslinked complexes of M1 RNA, the catalytic RNA subunit of ribonuclease P from Escherichia coli, and transfer RNA precursor substrates has led to the identification of regions in the enzyme and in the substrate that are in close physical proximity to each other.

Led by Yi - Ping Li, Ph.D., UAB professor of pathology, and Wei Chen, M.D., UAB associate professor of pathology, they investigated the key role played by Cbf - beta, or core - binding factor subunit beta.

The UAB research team, led by J. David Sweatt, Ph.D., chair of the Department of Neurobiology and director of the Evelyn F. McKnight Brain Institute, removed H2A.Z in mouse models by means of a genetically engineered virus so that the subunit exchange could not take place.

Using a technique called atomic force microscopy, Dilshan Balasuriya, led by Professor Mike Edwardson in Cambridge's Department of Pharmacology, imaged individual 3 trimers and confirmed that the complete 3 - subunit trimers cross-linked up to three sodium channel α - subunits.

The new Cambridge research was carried out by Sivakumar Namadurai and led by Dr Tony Jackson and Dr Dima Chirgadze from the University of Cambridge's Department of Biochemistry, and focussed on one of the - subunits, called β3.

To narrow down the list, a team of researchers led by Henry Lester, a neuroscientist at the California Institute of Technology in Pasadena, designed a mouse with a mutant version of the a4 * acetylcholine receptor subunit.

The project focuses on the dynamics of transient microcompartments formed by the V - ATPase holoenzyme, V - ATPase subcomplexes and subunits together with the mentioned proteins, with the aim to understand the mechanisms leading to this unique type of physiologically relevant regulation.

The RNAi - mediated silencing of both HTT alleles in neural stem cells derived from hESCs disrupted spindle orientation and led to the mislocalization of dynein, the p150Glued subunit of dynactin and the large nuclear mitotic apparatus (NuMA) protein.

The Transgenic and Archiving Module of the CCP (http://www.phenogenomics.cz/) is seeking a motivated post-doc or senior specialist to join our international team and lead the subunit of embryonic stem cell manipulation and transgenesis.

Dr Ho works in NIBSC since 1998 and leads R&D and standardisation projects collaborating with vaccine manufacturers in laboratory evaluation of product characterisation and quality control assays for novel bacterial vaccines, including protein subunit, polysaccharide - protein conjugates, viral vector and live bacterial vaccines.

The mutations that underlie the mitochondriopathies Myoclonic Epilepsy with Ragged Red Fibers (MERRF) and some variants of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes (MELAS) create defective versions of particular mitochondrial amino acid tRNAs, leading to inefficient translation of electron transport system (ETS) subunit proteins.

This little - heralded, meticulous investigation into the effects of ablation of the telomerase catalytic subunit in mice with human - like telomeres provides us with strong reassurance that, should it prove to be the preferred approach for implementing the OncoSENS strategy, the effects of knocking out TERT would be limited to those dictated by the loss of telomere - lengthening per se, and would not lead to an unintentional loss of some essential but hitherto - unknown phsyiological function.

RH5 is a leading subunit vaccine candidate because anti-RH5 antibodies inhibit parasite growth and the interaction with its erythrocyte receptor basigin is essential for invasion.

Aβ is believed to penetrate neuronal plasma membranes, where it leads to lipid peroxidation.10 It has also been implicated in deactivating a subunit of the pyruvate dehydrogenase complex, thereby inhibiting conversion of pyruvate to acetyl CoA and the eventual production of cellular energy as ATP.32 Another way Aβ affects glucose metabolism in the brain is that fragments of Aβ disrupt insulin signaling by binding to neuronal synapses, which alters their shape and function.15, 38 Insulin receptors are abundant at synapses, so if the integrity of the synapse itself has been compromised, the receptors won't function effectively.