Sentences with phrase «successful drug targets»

Overlap — Finally, successful drug targets significantly overlap with disease genes — those in which a mutation can cause a specific disease, such as cystic fibrosis — and with essential genes, that are required for normal development.

Not exact matches

Perepelkin says that failure applied to the pharmacies as well; for example, the Canadian pharmacies didn't carry Target's ClearRX trademark for prescription drug labelling that's been successful in the U.S.

The team was successful in getting the drug to piggyback on 123B9, an agent they devised to target an oncogene called EphA2 (ephrin type - A receptor 2).

«Conventional drugs targeting the enzymes encoded by MMP genes have not been successful in the clinic due to adverse side effects,» said Rahme.

By defining the threshold of the amount of virus needed for transmission, the research also provides a target that experimental dengue vaccines and drugs must prevent the virus from reaching in order to be successful at preventing the spread of disease during natural infection.

Nearly half of all melanomas contain BRAF mutations, which led to the successful creation and approval of new BRAF - targeting drugs.

The most notorious example of this class is HIV proteinase, commonly called HIV protease, which helps the virus cut a long polypeptide into functional proteins; it has become the target of several successful AIDS drugs.

Although doctors have long incorporated personal information like family history into treatment plans, personalized medicine holds the promise of revolutionizing medical care by using knowledge of molecular biology and genetics that will allow more precise diagnoses, better diagnostic tests, greater predictability of disease course, more successful therapies by targeting the right treatments to the right patients, and improved patient safety by selecting drugs and their proper dosage to reduce adverse side effects.

Based on analyses of over 600 drug and breast cancer cell pairings, researchers showed that, for some cells, drug exposure can cause significant changes in gene expression — indicating the successful action of a drug on its target — without affecting cell growth or survival.

Two groups of researchers - one an academic team from Barcelona, Spain; the other a biotech company from California called Sangamo - have just announced successful experiments using zinc finger drugs targeting the Huntington's disease gene.

Since RNA - based gene silencing drugs have been successful so far, why bother with the greater challenge of targeting the DNA of the huntingtin gene itself, especially if it means dealing with virus particles and big, fragile drugs made of protein?

In conclusion, anthelminthics as cancer drugs seem to lack specificity for molecular targets and lack safety profiles for systemic application in large part, such failing to fulfill the basic criteria for successful repurposing in oncology [3].

If successful, this would be the first drug to target neuropathic pain in specific areas without side effects, which is in stark contrast to the non-specific painkillers currently available.

To find out, the researchers looked at the relationships between 919 successful drugs, their human gene or protein targets, and the functional properties of those targets.

What characteristics, they asked, distinguished the targets that eventually became the focus of such successful drugs?

But successful demonstration of SLC6A14 as an effective drug target for treatment of selective subtypes of cancer would provide new hope even for patients with other types of cancers.