Sentences with phrase «such as apoptosis»

Abnormal Krebs cycle and / or oxidative phosphorylation cause (s) not only glucose hypometabolism but also the increased generation of reactive oxygen species (ROS), oxidative damage, and programmed cell death such as apoptosis.

Manuscripts that increase our understanding of the processes through which stem cells and progenitors differentiate into committed progeny, the commitment cell death programs such as apoptosis and necrosis, aging, and the transition between proliferation and cell cycle arrest are welcome.

Not exact matches

Made of a polymer that has already been approved by the FDA for applications such as biodegradable sutures, InVivo's implant seems to undermine the biological ripple effect that leads to apoptosis, essentially by leading the body to believe that the damage is not that bad, which tones down the immune response and helps the healthier neural tissue survive and heal.

The NLR family apoptosis inhibitory proteins (NAIPs) bind conserved bacterial ligands, such as the bacterial rod protein PrgJ, and recruit NLR family CARD - containing protein 4 (NLRC4) as the inflammasome adapter to activate innate immunity.

Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.

Apart from the EPO - EPOR changes, which are probably protective, it is not clear in most cases which gene changes help the retina survive hypoxia, and which may participate in detrimental effects such as neovascularization and apoptosis.

Other p53 targets contribute to apoptosis induction, such as Bax, Noxa, and p53AIP1 (20, 22), or to the maintenance of genomic stability, such as GADD45a (25).

Cytotoxicity was enhanced by alterations of the regulators of apoptosis, such as Bcl2 / XIAP, in melanoma, lung cancer and adrenocortical carcinoma [9, 19, 21, 67].

Moreover, there are yet other cell types — such as visceral adipose tissue macrophages and cytotoxic CD8 + T - cells — in which the age - related supernumerary accumulation of dysfunctional and apoptosis - resistant cells appears to play a highly deleterious role on tissue function, but where the cells are not «senescent» cells in the classical sense of p16Ink4a expression and the senescence - associated secretory profile observed in senescent fibroblasts.

Morphologic examination of the Hoechst - stained cell preparations at 16 hours after treatment with 20 nmol / L rapamycin showed morphologic evidence of apoptosis, such as nuclear condensation and fragmentation in ALCL cells (A, bottom right).

Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), are known to be vulnerable to apoptosis upon various technical manipulation, such as single cell dissociation, freezing and thawing, etc., which hinder their use for clonal isolation in gene transfer, differentiation and FACS cell sorting.

PromoKine offers a wide range of well proven products for cell biology research such as kits and reagents for cell analysis, apoptosis research, cell transfection, fluorescent labeling, gene cloning & expression, mycoplasma detection and elimination as well as numerous antibodies, ELISAs, cytokines and growth factors.

What Sattler did focus on at Abbott was the structural biology of apoptosis regulators, such as the Bcl2 protein family.

Uncoupling cell proliferation from apoptosis and possibly from cell migration can lead to pathologies such as cancer.

Fluorescent probes can be used to detect different parameters such as: cell cycle, proliferation, apoptosis, pH changes and calcium flux.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

Notably, genes thought to induce and promote apoptosis through the intrinsic mitochondrial apoptotic pathway, such as KLF10 [32], were not altered in differentiated cells or in treated versus untreated cells.

Fluorescence - based assays Fluorescent markers such as EGFP, YFP, mCherry and mTomato or fluorescent biosensors can be used to measure a variety of real - time cell - based activities, including, intracellular transport, protein signaling, receptor desensitization, migration, division, apoptosis, metabolism, differentiation, chemotaxis, transcription and translation.

Many mechanisms of MDR have been described, such as the overexpression of MDR1 (also known as P - glycoprotein or ABCB1) or other ATP - dependent transporters that pump drugs out of the cancer cells, amplification of drug - inactivating enzymes, mutations or modifications of drug targets, alterations in DNA repair machinery, and increased resistance to apoptosis (1 — 3).

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

There was no significant enrichment of genes in any functional category; however, GO annotations revealed 34 DEGs involved in biological processes important to the establishment of pregnancy, such as «regulation of apoptosis,» «vasculature development,» «neurogenesis,» «positive regulation of cell differentiation,» «Wnt receptor signaling pathway,» and «gland development.»

The drugs reduce pain and inflammation by inhibiting the cyclooxygenase (COX) enzymes, which are involved not only with inflammation but also with certain processes involved in cancer, such as blood supply to the tumor and programmed cell death (known as apoptosis).

Earlier research suggests these compounds are able to negatively affect critical cancer cell mechanisms, such as those responsible for programmed cell death (apoptosis) and for proliferation.

CB2 cannabinoid agonists such as WIN55,212 - 2 inhibit experimental autoimmune encephalomyelitis (EAE), an animal model of MS, by mediating apoptosis of the encephalitogenic cells that induce brain inflammation (41).

Dr. Lee and Dr. Zava cited research studies which show that progesterone receptors activate genes such as p53 that promote apoptosis.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

Diet - induced changes in tumor growth occur in parallel with changes in tumor biomarkers such as proliferation and apoptosis which are associated with improved clinical outcomes in humans.

Functional Nutriments Through pet specialty retailers, the company offers proprietary canine nutraceuticals with ingredients such as curcumin and luteolin, which support apoptosis, or natural cell health.