Sentences with phrase «such as growth factor»

It has been observed that this pathway when is activated by upstream signaling cascades [such as growth factor receptors and G - protein coupled receptors (GPCRs)-RSB-, leads to cell proliferation, differentiation and migration.

Conditions that stimulate cell growth, such as growth factors and nutrients, activate rDNA transcription, whereas external signals that harm cell growth inhibit transcription.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Many factors come into play such as initial cost, fees, and growth trend forecasting when buying a franchise.

The functional effectiveness of such electronic sharing systems has been one factor in the growth of telecommuting as an option for workers.

Some of the possible excess in house prices could in the interval be tempered by factors such as income growth, regulatory changes and modest price corrections along the way.

It wasn't immediately clear how much of the change reflected confidence that the tax - cut legislation moving through Congress will boost growth, or other factors such as pickups in business spending and global growth.

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personSuch risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personsuch availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personsuch approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

You should also be considering factors such as organizational structure, end - customer demographics, cash flow strength and growth projections.

Here are the top 10 pizza chains from Entrepreneur's Franchise 500 list, as measured by such factors as financial strength and stability, growth rate, breadth, experience and startup costs.

The recent slowdown in job market growth, along with other factors such as the U.K.'s upcoming Brexit vote, have contributed to the central bank's more cautious approach.

The portfolio management team uses a variety of investment strategies to search for companies suitable for investment in the fund, including factors such as growth in earnings, return on equity, and revenue.

A few also cited regulatory factors, such as cap - and - trade policies in Ontario and the carbon tax in Alberta, as contributing to their input price growth.

Exchange traded funds (ETFs), such as the iShares Short Maturity Bond ETF (NEAR), the iShares MSCI USA Quality Factor ETF (QUAL), the iShares Core Dividend Growth ETF (DGRO), and the iShares MSCI Japan ETF (EWJ), can provide access to short duration bonds, high quality companies, and Japan.

But thereafter, factors such as the stock chart pattern and company earnings growth become part of the criteria for picking which stocks to swing trade.

By scoring BTC and ETH through these attributes, teams were able to objectively manage data into their case studies, along with other real world factors such as commercial application, and projected growth affected by various trends in the crypto world.

at 989 (observing that an «against» recommendation from ISS «overshadow [s]» other performance factors such as the growth of CEO pay); id.

By combining factors such as budget, market growth, current pipeline, and past trends, companies can make projections about short - term and long - term sales figures.

Those data are namely 1) the recent rally in stocks, 2) the recent improvement in the ISM (formerly NAPM) surveys, and 3) the substantial string of Fed easings «in the pipeline», which have accelerated growth in broad money such as M2, and 4) the likelihood that inventories will stabilize, taking away the biggest negative factor currently pressuring GDP lower.

Meanwhile, some of the external factors that helped to drive profit growth in the past three decades, such as global labor arbitrage and falling interest rates, are reaching their limits.

The disappointing performance of business investment to date could reflect more sustained structural factors, such as slowing labour force growth, low productivity growth and regulatory obstacles.

They need to consider the valuation relative to other companies depending on several factors such as growth rate, capital structure, revenue, risk profile, and net income.

Structural factors such as aging populations, poor productivity growth and high debt levels mean historically low government bond yields are likely here to stay.

In contrast, export volumes decreased over this period, despite strong global demand, as capacity and infrastructure constraints and supply disruptions restricted growth; such supply - side factors have hampered exports for a number of years, with resource export volumes now lower than during 2000 (see the chapter entitled «Australia's Resource Exports — Recent Trends and Prospects» in this Statement).

Other factors can also be considered, such as the amount you request, years in business and growth trajectory.

A variety of factors — such as the outlook for economic growth and inflation, supply and demand for credit, market sentiment, and other factors beyond the Fed's control — impact long - term rates.

Instead, factors such as inflation, interest rates and global growth are much more important to markets.

There have been periods of time when exposure factors can, and have underperformed the market, such as dividend growth stocks over the last four years.

While profits of most of the listed companies in the S&P 500 Index showed robust growth, there are a number of underlying factors such as wage growth, consumer spending, auto and home sales that need to expand significantly.

And while equity markets have been performing well this year, there are numerous potential risk factors that could cause a sharp correction in the equity markets, such as the U.S. election, sluggish global economic growth and the future of Europe given the «Brexit» situation.

The pace of growth moderated in early 2003, however, in line with the easing in the rate of growth of domestic spending and the dropping - out of one - off factors such as large purchases of civil aircraft.

The cities were determined by factors such as access to talent, investment capital and growth opportunity.

Some reports, such as the Open Philanthropy Project's Animal Product Alternatives report and Van der Weele & Tramper (2014) suggest it is unlikely that cultured meats will become cost - competitive with conventional meat.98, 99 One important contributing factor in this conclusion, which is cited in these reports, is the minimum costs of the growth medium necessary for culturing the desired cells.

The general U.S. market may tank due to a variety of factors, such as a combination of international and domestic events, from reports of high speculation in real estate markets to poor economic growth and growing debt.

At the same time, macro-economic factors such as slowing commodity prices, weakening growth of emerging markets and concerning geopolitical pressures, have also hit the banks hard.

Global demand for Bitcoins is influenced by such factors as the growth of retail merchants» and commercial businesses» acceptance of Bitcoins as payment, the security of online Bitcoin Exchanges and digital wallets that hold Bitcoins, the perception that the use of Bitcoins is safe and secure, and the lack of regulatory restrictions on their use.

Other factors clearly played a part in this development, not least the unrelated growth, during this period, in the numbers of independent women who had the freedom to join a new cult such as Christianity.

b Secondly we must enlarge our approach to encompass the formation, taking place before our eyes and arising out of this factor of hominization, of a particular biological entity such as has never before existed on earth — the growth, outside and above the biosphere, (This term, invented by Suess, is sometimes interpreted (Vernadsky) in the sense of the «terrestrial zone containing life».

Involvement in the multitudinous problems of a rapidly expanding urban area or exposure to the increasingly bitter struggle between labor and management or entanglement in the luxuriant and rank growth so abundantly fostered by the new wealth of the «gilded age»: these and other factors caused many men to re-examine their roles as ministers and to seek more effective ways of ministering to the needs of their time.11 Perhaps the most important thing that happened to such men was that they became aware of the many factors bearing on human welfare and thus of importance to the Christian gospel.

High - quality ingredients such as sun - ripened jalapeño, cayenne, habanero and Tabasco peppers are the heart of the product, but it's the uniqueness factor that draws customers in and continues to fuel the company's growth.

The growth of the French packaging industry will be heavily influenced by changing demographics and social factors such as a high employment rate and a large aging population, which have a clear impact on consumer spending power and purchasing habits...

Again, factors such as the temperature of your dough and surrounding environment will effect the growth rate.

The development in this larger, wide mouth neck finish is driven by the combination of three factors: - the continuous growth of aseptically processed, shelf stable beverages such as juices, drinkable dairy, Ready - To - Drink coffees and teas, preservative free drinks and water - the dynamic growth of on - the - go beverage consumption in single serve packaging formats - and the increasing consumer demand for on - the - go beverage convenience, hygiene and resealablity provided by a flip - top sport cap with a larger neck finish for superior hydration.

This growth is expected to be driven by factors such as raising health concerns among the consumers, new product launches by leading companies and aggressive marketing by retailers about gluten - free products.

Consumer focus on wellness, environmental impact and macroeconomic factors such as the growth of the middle class creating more disposable income are shaping the global packaging market, said Charles D. Yuska, president and CEO, PMMI.

Strong favorable demographic factors such as increasing disposable income levels and spending capabilities, rising consumer awareness and a hectic lifestyle of busy professionals are driving the growth of the packaging industry in Indonesia.

HPP has gained worldwide acceptance as a safety step in beverage processing and it's use is seeing rapid growth, fueled by market factors such as the high demand for safe and nutritious fruit and vegetable juices, coconut waters and fruit purees.

While some of these factors, such as food safety concerns and technological innovations, are unpredictable in magnitude and timing, others are observable (e.g. income growth), constrained by supply side factors (e.g. lack of feed) and determined by institutional changes (e.g. harmonization of standards) and policies (e.g. agricultural subsidies and environmental regulations).

Factors such as population growth, growing demand for automation and machinery optimisation, as well as a rise in e-commerce is fuelling this development,» said Jorge Izquierdo, VP of Market Development at PMMI.

The role of bioactive components, such as cytokines, hormones, growth factors (GFs) and fatty acids (FAs) is poorly known, but they might be implicated in immune response development.