Sentences with phrase «such as transcription factor»

ALFA compiles the current state - of - art about the annotations of DNA regulatory elements (such as transcription factor binding sites, microRNA target sites) for a better understanding of biological processes underlying rare diseases.

Currently, enhancers can be identified through chromatin - based assays, such as ChIP - seq, which predict enhancer elements indirectly based on the enhancer's association with specific epigenomic marks, such as transcription factors or molecular tags on DNA - associated histone proteins.

Together, the discovery of such rapid dynamic modes within chromatin fibers provides new insight how processes can gain access to the DNA (or are prevented to do so), such as transcription factors, or the machinery for transcription, replication or DNA repair.

Are there new technologies to inhibit traditionally «undruggable» target molecules, such as transcription factors, that are required for the oncogenic phenotype?

ChIP - Seq is a powerful tool to study genetic regulation, because it enables one to accurately identify regions of DNA bound by specific proteins, such as transcription factors or RNA Polymerase II components.

In contrast, many scientists consider that chromatin does not form an independent epigenetic layer of the genome and that chromatin modifiers do not operate independently of a DNA sequence specific targeting mechanism, such as transcription factors.

Not exact matches

We know that Hox genes encode transcription factors that control the activity of other genes, but we found that digit - innervating motor neurons also express other genes, such as FIGN and CNEP4], and we still don't know the function of any of these other genes.

The genes for each transcription factor were made from different bits of DNA that code for the functional parts of proteins, such as a domain that can bind to DNA and another that provides the protein with access to the cell's nucleus.

Since its development, lattice light - sheet microscopy has been used to image numerous important events, such as single transcription factor molecules binding to DNA, hotspots of transcription, microtubule instability, protein distributions in embryos, and much more.

As a monomer, GR represses the activities of pro-inflammatory transcription factors, such as activator protein 1 or nuclear factor kappa B (NF - kB) by a tethering mechanism called transrepressioAs a monomer, GR represses the activities of pro-inflammatory transcription factors, such as activator protein 1 or nuclear factor kappa B (NF - kB) by a tethering mechanism called transrepressioas activator protein 1 or nuclear factor kappa B (NF - kB) by a tethering mechanism called transrepression.

The master regulator transcription factors and super-enhancers work together to regulate the expression of critical genes, such as those responsible for cell identity.

Previously, in the region that controls the function of the transcription factor that promotes differentiation from ES cells to a specific cell type, bivalent modifications of histones such as the accelerator and brake histone marks for transcription were thought to have coexisted.

Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.

Conditions that stimulate cell growth, such as growth factors and nutrients, activate rDNA transcription, whereas external signals that harm cell growth inhibit transcription.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

A successful candidate should have the following qualifications: a Ph.D. in the field of Molecular Biology, Cell Biology, Biochemistry or related field; an established track - record of publications in peer - reviewed journals; solid experience in the biochemistry of complex DNA - binding proteins (such as chromatin remodeling factors or DNA repair proteins), their purification from heterologous expression systems as well as their characterization using functional studies such as by isothermal titration calorimetry fluorescence, transcription assays.

Besides, some other potential cis - acting elements for transcription factors [such as CAAT / enhancer binding protein (C / EBP) and PU.1] have been also noted in the RIG - G gene promoter.

In the second webinar, you will learn how to apply basic concepts of flow cytometry to topics such as cell proliferation, dead cell exclusion, and intracellular staining techniques for transcription factors and phospho - proteins.

These include the early duplication of transcription factor families such as homeodomains and basic helix — loop — helix domains13, 14,27.

Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a signal transduction pathway that appears to involve an amino acid sensing GPR [37].

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

For example, our studies identified transcription factors, RNA binding proteins, and signaling genes as critical miRNA targets during contexts such as development of peripheral sensory organs, wing, eye, and CNS, or during behavioral contexts such as egg - laying, rhythmic behavior, and locomotor activity (Figure 2).

ES cells can be described based on a characteristic morphology, the presence of cell surface markers such as SSEA - 1 and Pecam1, or the expression of the key transcription factors such as Oct4, Sox2, Nanog, and a number of ES cell - specific transcripts (ECATs)[4]--[6].

Measurements that are increasingly available range from those that identify transcription factor occupancy and initiation of transcription to long - lasting and heritable epigenetic marks such as DNA methylation.

The FunGenES database provides such a template with a number of tools including Animation of KEGG Pathways, Expression Waves, Time Series, Specific Gene Classes, such as ESTs and transcription factors, and searches for the expression pattern of any gene or transcript during ES cell differentiation using standard gene names and IDs.

For cell reprogramming, there are about 2,000 known transcription factors that might be useful in changing a cell from one state to another, such as creating induced pluripotent stem (iPS) cells from skin cells.

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

Studies have identified transcription factors such as Stat3, Nanog, and Oct4 as being necessary for embryonic stem (ES) cell self - renewal and maintenance of pluripotency.

The workshop will focus on topics such as; hematopoietic stem cell biology, leukemogenesis, cell signaling, transcription factors, epigenetic effects, and other topics related to myeloid biology.

Scientists aren't exactly sure, but in line with the study on NF - KappaB, they believe that glycine acts directly on inflammatory cells such as macrophages to suppress activation of transcription factors and the formation of inflammatory cytokines in the first place.

Notably, ROS can directly or indirectly activate transcription factors such as NF - kB and AP - 1 that can promote inflammation.»

HSF4 belongs to a family of heat shock transcription factors that regulate the expression of heat shock proteins in response to different stresses, such as oxidants, heavy metals, elevated temperatures and bacterial and viral infections [96].

As for myself, I will pick up articles in prebiotic chemistry, virology as it relates to retroviruses or bacterial viruses, or molecular biology, such as those dealing with new discoveries related to promoters, transcription factors (proteins and RNAs which regulate the expression of other proteins and RNAs by binding to promoters), but even after having read a fair amount, trying to fit together pieces in a puzzle, I will be lucky if I have actually understood more than half of a given article at a relatively basic leveAs for myself, I will pick up articles in prebiotic chemistry, virology as it relates to retroviruses or bacterial viruses, or molecular biology, such as those dealing with new discoveries related to promoters, transcription factors (proteins and RNAs which regulate the expression of other proteins and RNAs by binding to promoters), but even after having read a fair amount, trying to fit together pieces in a puzzle, I will be lucky if I have actually understood more than half of a given article at a relatively basic leveas it relates to retroviruses or bacterial viruses, or molecular biology, such as those dealing with new discoveries related to promoters, transcription factors (proteins and RNAs which regulate the expression of other proteins and RNAs by binding to promoters), but even after having read a fair amount, trying to fit together pieces in a puzzle, I will be lucky if I have actually understood more than half of a given article at a relatively basic leveas those dealing with new discoveries related to promoters, transcription factors (proteins and RNAs which regulate the expression of other proteins and RNAs by binding to promoters), but even after having read a fair amount, trying to fit together pieces in a puzzle, I will be lucky if I have actually understood more than half of a given article at a relatively basic level.

STAT6 is part of the STAT family of transcription factors, its phosphorylation in response to cytokines and growth factors activates the transcription of many genes involved in the immune system such as interleukin 4 (IL - 4).