The problem with consuming these synthetic versions of vitamin C is it is very easy to go overboard as they often come in
such high doses.
Such high doses create undesirable metabolites and unnecessarily overload the liver.
I learned about Benfotiamine from this article in Life Extension (http://www.lifeextension.com/Magazine/2008/4/Protecting-Against-Glycation-High-Blood-Sugar-With-Benfotiamine/Page-01) which claims that therapeutic doses have been used up to 1000 mg / day without adverse effects, but it's not clear for how long
such high doses were administered.
I would recommend sulfur - containing foods like onion and garlic and N - acetylcysteine as a supplement, but avoiding MSM — especially in
such high doses.
However, amounts greater than 2,000 mg / day are not recommended because
such high doses can lead to stomach upset and diarrhea.
Given the relatively very high doses used in the study on the whole and the fact that only mild toxicity was reported, I would say that this conclusion appears to be valid but I would like to see more studies using high
such high doses for comparison in order to truly validate these findings.
Sheri Weaver also explains that most of the over-the-counter pain relief creams have
such high doses of menthol.
In fact, in this case, «antioxidants are preventing the health effects of exercise,» adds Ristow, although he cautions that not all vitamin supplements contain
such high doses of vitamin C and E.
If a woman with diabetes or hypothyroidism takes
such high doses of fenugreek by pill that her urine and sweat start to smell like maple syrup, that means her blood sugar and thyroid level could be altered.
Research suggests that about a third of kids are lucky enough to escape trauma, but about a quarter suffer
such high doses that it affects brain development, immune and endocrine functioning, and can create mental and physical disease systems that reduce the lifespan by an average of 20 years.
Cows are often milked during pregnancy, when their estrogen levels are highest, which is why cow's milk can contain
such high doses of estrogen.
It's also been reported that
such high doses can also produce its own euphoric effects.
With
such a high dose of phytoestrogens, women who have the opposite problem (too much estrogen) could really be hindered by upping their intake.
And it makes me wonder (this has been my experience) that feeding the gut
such high dose B12 supplements might actually make the SIBO issue far worse.
It's important to note that taking
such a high dose of zinc as in this study on a long - term basis may impair our ability to absorb copper.
Not exact matches
There are some toxins,
such as alcohol, that your body can deal with at a low level and that will kill you only at
high doses.
The best ingredients to include in a green juice for a
high dose of nutrition include kale, Swiss chard, bok choy, dandelion greens, spinach, watercress, baby kale and herbs
such as parsley.
High doses of whey can cause effects
such as cramps, nausea, headache, and stomach pain.
Muscle contractions,
such as those that are activated to help push out a baby, can also be triggered by
high potassium
doses.
For example, if you've given birth to a baby who has a neural tube defect, your health care provider might recommend a separate supplement containing a
higher dose of folic acid —
such as 4 milligrams (4,000 micrograms)-- before and during any subsequent pregnancies.
This would help tamp down antibiotic resistance, while allowing doctors to lower the dosage of antibiotics that are toxic at
high doses and that produce nasty side effects
such as deafness and kidney damage.
In addition, the
high doses of antibiotics needed to kill
such an infection indiscriminately destroy healthy red blood cells in addition to contaminated ones.
Moreover, companies are moving into the use of new types of therapeutic proteins
such as antibodies, which are only effective at
high doses.
They had thought that it would take
higher doses to achieve
such a result.
Over about 3.5 years, 535 of 3344 people in the placebo group suffered
such an «event,» compared with 642 of 4547 getting the medium and
high doses.
As Langer notes,
high -
dose drugs,
such as antibiotics, probably are better administered in other ways.
Low
doses also protect against the harmful effects of
higher, toxic
doses of lithium and other substances
such as the pesticide paraquat,» said co-author Dr Ivana Bjedov from the UCL Cancer Institute.
Such opioids could help patients and doctors deal with drug tolerance, a frequent complication in which, over time, patients lose sensitivity to the pain - blocking properties of opioids and require
higher doses to treat their pain.
In some cases, patients» tumors develop resistance to Gleevec — either the Abl protein mutates so that the drug can no longer bind to it, or the protein accumulates in
such quantities that the drug can't keep up, even at the
highest dose.
Vandenberg and Catanese report that «although these same effects were not seen at the
higher dose, more than 10 percent of females exposed to 2 microgram BPS / kg / day either killed their pups or provided
such poor instrumental maternal care that one or more pups needed to be euthanized.
And in tracking human disease patterns, she's established a clear link between
such low -
dose chronic exposure and increases in
high blood pressure and heart disease.
Reactivation of HBV may occur with chemotherapy, organ and tissue transplantation,
High dose corticosteroids, and biologicals targeting tumor necrosis factor - alpha (TNF - α), Anti-TNF medications are used in treating rheumatic diseases,
such as rheumatoid arthritis, digestive conditions that include Crohn's and colitis, and dermatologic conditions,
such as psoriasis.
Spark CEO Jeff Marrazzo says their more potent vector and differences in how the treatment is made,
such as the company's use of a surfactant to make sure the vector doesn't stick to the vial when the surgeon injects it, may result in a
higher dose of the RPE65 gene getting into retinal cells and long - lasting effects.
The studies (though conducted almost entirely in men) showed that there's a definite interaction between flibanserin and alcohol, with an increased number of side effects
such as dizziness and fainting at moderate and
high alcohol
doses.
Rao's team is now using this data to develop a new approach to forecasting patients» seizure risk, which could allow patients to avoid potentially dangerous activities
such as swimming or driving when their seizure risk is
highest, and to potentially take steps (
such as additional medication
doses) to reduce their seizure risk, similar to how people with asthma know to take extra care to bring their inhalers when pollen levels are
high.
When insects from
such a species carry two copies of a resistance gene, they can survive
high doses of Bt.
While these imaging procedures, including fluoroscopically guided procedures
such as cardiac catheterization, computed tomography scans, and nuclear medicine studies, are critical for accurate diagnosis and intervention, ionizing radiation in
high doses can be harmful.
The secondary analysis suggested a
dose - response relationship,
such that
higher vericiguat
doses were associated with greater reductions in NT - proBNP level.
The total radiation delivered, 0.5 gray (Gy), was
high relative to environmental levels (from sources
such as naturally occurring radon in rock), but significantly lower than equivalent human
doses experienced in CAT - scans or cancer therapy.
The mixture included chemicals
such as phthalates, pesticides, bisphenol A and parabens as well as the painkiller paracetamol, and was given in
higher doses than humans are exposed to.
On the basis of the current studies as well as previous reports on the use of intradermal immunization against influenza, hepatitis B, rabies, and other infectious diseases, 2,3,8 it is becoming clear that use of the intradermal route may at least partially overcome the relatively poor influenza - specific immune responses seen in certain at - risk populations, particularly the elderly, in whom the immune response in general is known to diminish with age.9 Moreover, in times of shortage, the
dose - sparing intradermal approach might be particularly well suited to the young, healthy persons included in the CDC's
high - priority group for vaccination,
such as health care workers, as well as to younger, otherwise healthy populations in general.
Influenza remains a major health problem in the United States, resulting each year in an estimated 36,000 deaths and 200,000 hospitalizations.4 Those who have been shown to be at
high risk for the complications of influenza infection are children 6 to 23 months of age; healthy persons 65 years of age or older; adults and children with chronic diseases, including asthma, heart and lung disease, and diabetes; residents of nursing homes and other long - term care facilities; and pregnant women.4 It is for this reason that the Centers for Disease Control and Prevention (CDC) has recommended that these groups, together with health care workers and others with direct patient - care responsibilities, should be given priority for influenza vaccination this season in the face of the current shortage.1 Other
high - priority groups include children and teenagers 6 months to 18 years of age whose underlying medical condition requires the daily use of aspirin and household members and out - of - home caregivers of infants less than 6 months old.1 Hence, in the case of vaccine shortages resulting either from the unanticipated loss of expected supplies or from the emergence of greater - than - expected global influenza activity —
such as pandemic influenza, which would prompt a greater demand for vaccination5 — the capability of extending existing vaccine supplies by using alternative routes of vaccination that would require smaller
doses could have important public health implications.
Currently, lymphadenectomy is an eligibility requirement for cutting - edge adjuvant therapy trials
such as Southwest Oncology Group (SWOG) 1404 (ClinicalTrials.gov identifier: NCT02506153), which randomizes stage III melanoma patients to an anti — programmed death 1 antibody or standard - of - care adjuvant therapy (
high -
dose interferon or
high -
dose ipilimumab).
This information is a result of the decrease in malondialdehyde concentrations that occur when
high doses of onion juice were given to the subjects.The researchers suspect that the antioxidants in question are probably selenium compounds found in onions, and phenols
such as quercetin and isorhamnetin.
«It's recommended a
high quality
dose of protein
such as dairy, egg or lean meat post - workout is beneficial to maximally stimulate muscle protein synthesis.
For this reason,
high doses of vitamin E are not recommended for people taking blood - thinners
such as warfarin (Coumadin) and aspirin.
In our opinion, children with chronic illnesses
such as autism, diabetes, and / or frequent infections should be supplemented with
higher doses of sunshine or vitamin D3,
doses adequate to maintain their 25 (OH) D levels in the mid-normal of the reference range (65 ng / mL)-- and should be so supplemented year - round (p. 868).»
SABOTEURS: If you're on anticoagulant medication
such as aspirin and warfarin, be wary of
high doses of EFAs.
Since refined carbohydrates
such as bread raise blood glucose significantly more than dietary fat, this required
higher insulin
dosing in type 1 diabetics to keep blood glucose control.
Extended use or excessively
high doses of juniper supplements may cause serious side effects,
such as kidney irritation or seizures.