«This study is important because it has the potential to change the way we approach kidney transplantation,» says the study's principal investigator, E. Steve Woodle, MD, UC Health transplant surgeon and director of the division of transplantation at the UC College of Medicine, who adds: «This also may benefit 10 to 20 percent of heart and pancreas transplant candidates who often have
such high levels of antibodies that transplantation is nearly impossible.»
Not exact matches
High levels of such antibodies are made in approximately 20 percent
of individuals with HIV infection.
The study, published in the Inflammatory Bowel Disease Journal, evaluated the
levels of infliximab, an
antibody designed to bind to and block the effects
of TNF - alpha, an inflammatory protein found in
high levels in patients with IBD,
such as Crohn's disease and ulcerative colitis, and numerous other inflammatory conditions
such as rheumatoid arthritis and psoriasis.
To establish whether a kennel has parvovirus, test some
of the breeding animals for
antibodies, their titres will be much
higher if they have been naturally exposed compared to post-vaccinal
levels (
such tests can be carried out by Companion Animal Diagnostics, University
of Glasgow Veterinary School).