Sentences with phrase «such large trials»

Not exact matches

«[A.I.] can help analyze large data sets from sources such as clinical trials, health records, genetic profiles, and preclinical studies; within this data, it can recognize patterns and trends and develop hypotheses at a much faster rate than researchers alone,» says Deloitte.

Clearly, additional large randomize trials are needed to further understand the possibility of using probiotics to manage infant colic crying and which subgroup of infant could potentially profit from such intervention.

Most trials of prenatal home visiting have produced disappointing effects on pregnancy outcomes such as birth weight and gestational age, 9,16,17 although one program of prenatal and infancy home visiting by nurses has reduced prenatal tobacco use in two trials18, 19 and has reduced pregnancy - induced hypertension in a large sample of African - Americans.20

In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.

The Feedback Intervention Trial (FIT) is the first such trial to be done in a large number of hospitals anywhere in the wTrial (FIT) is the first such trial to be done in a large number of hospitals anywhere in the wtrial to be done in a large number of hospitals anywhere in the world.

As Scientific American reported earlier this year, more than half of the current cancer clinical trials do incorporate some form of immunotherapy but still oncologists are often only in the early stages of understanding how to use such treatment on a larger scale.

It's probably clinical trials in large populations, such as testing to see if a reduced - salt diet reduces blood pressure.

«Such biases, conscious or unconscious, can make candidate medical treatments look better than they actually are, the authors of the analysis warn, and lead to eye - catching results that can't be replicated in larger or more rigorous animal studies — or in human trials.»

Chip potential If the chip proves successful in larger and longer trials, it might also be adapted for treating more acute conditions, such as delivering drugs for a month or two after a heart attack.

If enacted, such a regulatory scheme could conceivably speed along clinical trials because it would allow investigators to draw from a large pool of people with diverse tumors that act along the same pathway instead of culling thousands of people with the same official cancer type.

The attendees developed a list of top research priorities and a research agenda for exercise in solid organ transplant, which includes the need to conduct large multicenter intervention studies, standardize measures of physical function in clinical trials, examine the benefits of novel types of exercise, and assess the effects of exercise on measures such as immunity, infection, and cognition.

... Finally, this study draws attention to the need for large controlled clinical trials to determine if a combination of fall prevention strategies and treatment with bone - active drugs might produce additive benefits on fractures, especially in high - risk populations such as those living in nursing homes.

Osaka University scientists found that some potential γ — secretase inhibitors such as semagacestat, which have been used in large clinical trials that ended in failure, do not function as true inhibitors as originally expected, but rather cause accumulation of toxic intraneuronal Aβ.

«Our next step is to perform a larger clinical trial for a longer period of time in both healthy individuals and large groups of athletes such as cyclists or long - distance runners.»

Such a large randomized trial was recently completed that included both apparently healthy individuals as well as those with severe mental illness.

Larger, well - designed studies, such as cluster randomized trials, are ultimately needed to confirm the effectiveness of this strategy,» writes Alice Y. Guh, M.D., M.P.H., and L. Clifford McDonald, M.D., of the Centers for Disease Control and Prevention, Atlanta.

«There are a lot of questions about how to implement it,» says Connie Celum, an HIV researcher at the University of Washington in Seattle, who led a large trial of the drug in East Africa and has begun studies to answer practical delivery questions, such as which subsets of people are at highest risk.

A few committee members argued today that no one would ever know the true risk of Avandia without such a study, but others worried that the trial's large reach and long extent — it will run for 8 years — could put more patients in harm's way.

«Large - scale clinical sequencing and molecular profiling can better inform collaborative programs such as the National Cancer Institute - Children's Oncology Group Pediatric MATCH clinical trials and the Pacific Neuro - Oncology Consortium.

Eating a non-calorie restricted Mediterranean diet high in vegetable fats such as olive oil or nuts does not lead to significant weight gain compared to a low - fat diet, according to a large randomised trial published in The Lancet Diabetes & Endocrinology journal.

Another limitation is that the trial did not select patients who were at the highest risk for developing another arterial blockage, such as those over age 65, those who have had more than one heart attack or those known to have a large number of blood clots.

Our current research combined with information from large clinical trials with antioxidants suggests that people who have been recently diagnosed with cancer should avoid such supplements.»

Previous studies, including large - scale trials in China, have shown that cruciferous vegetables that have a high concentration of sulforaphane — such as broccoli, cabbage and garden cress — help mitigate the effects of environmental carcinogens.

In 2002, the research team for TRIGR (Trial to Reduce IDDM in the Genetically at Risk), led in the U.S. by principal investigator Dorothy Becker, M.D., professor of pediatrics at Children's Hospital and the University of Pittsburgh School of Medicine, embarked on a large - scale study of 2,159 infants with a family member affected by type 1 diabetes and with genetic risk for type 1 diabetes to find out whether delaying the exposure to complex foreign proteins such as cow's milk proteins would decrease the risk of diabetes.

Researchers leading the largest genomic tumor profiling effort of its kind say such studies are technically feasible in a broad population of adult and pediatric patients with many different types of cancer, and that some patients can benefit by receiving precision drugs targeted to their tumors» mutations or being enrolled in clinical trials.

Small, focused clinical trials are possible for certain B - cell malignancies such as Diffuse Large B - Cell Lymphoma in which patients can be stratified based on NF - kB activation status and / or presence of mutations known to activate NF - kB.

«Our next goal is to replicate these experiments and test their safety in larger mammals, such as pigs, before considering clinical trials in humans,» added Dr. Srivastava, who is also a professor at the University of California, San Francisco (UCSF), with which Gladstone is affiliated.

Applications involving contracts (such as used for large, multicenter clinical trials) were not included in these analyses.

When I lecture on heart health, I draw from nutrition studies such as the Adventist Health Study of nearly 100,000 participants, the EPIC - Heart trials with more than 500,000 subjects, and other large collections of observations.

Holick says there's reason to believe higher doses, such as the 2,000 IU a day now being tested in one large U.S. trial, are needed to produce benefits.

However, a good plus size dating site offers a free sign up trial, such as Large Friends.

Singles dating sites across America are offering their members incentives to retain and create new business such as the chance to win holidays, thirty day free trial memberships, buy a six month subscription get six months free, and a «find a match guarantee» Several of the largest American online dating sites use pure clout to attract new business by annually spending millions of dollars on television commercials.

Although this trial and error mechanic can be rewarding, at times it feels unfair such as in larger areas where you can't quite see where the enemies are before it's too late.

The results of the trial will only strengthen the larger story of race and inequality, while the motel's occupants attempt to deal with witnessing such a horrific personal tragedy.

The stage was set with the two public education luminaries, ready to square off on such lightning rod issues as tenure and teacher dismissal laws in the wake of last month's Vergara trial: Randi Weingarten, leader of the nation's second largest teachers organization, AFT, and Superintendent John Deasy, leader of the second largest school district in the...

Fundamental news items such as strong earnings reports and raised guidance, FDA approvals, successful clinical trials, outside investments, partnerships / joint ventures with larger peer companies, successful court rulings, patent news and analyst upgrades can fuel a short squeeze.

The therapeutic dotential of dietary precursor modulation by a fish - oil - supplemented diet (n - 3 fatty acids), such as eicosapentaenoic acid (C20: 5,n - 3) and docosahexaenoic acid (C22: 6,n - 3) in the therapy of ulcerative colitis has been shown to result in a 35 % to 50 % decrease in neutrophil production of LTB4.28 Significant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fatty acids.

There are two exceptions, for my money: The Arkham games, since taking down a large group of enemies required such precision and fluidity (though that wasn't DLC, so maybe that doesn't even count) and Dishonored «s much - more - fun - than - I - expected «Dunwall City Trials» which, by focusing purely on individual elements of gameplay, ended up feeling very different from the base game.

Large - scale works encompass the issues that he was most interested in, such as the Rosenberg trial (Les roses sont belles [The Roses are Beautiful]-RRB- in 1951; torture in Algeria (La question Djamila [The Djamila Question]-RRB- in 1957; the execution of Julian Grimau (Les puissances du désordre [The Powers of Disorder]-RRB- in 1963; and the Vietnam war (Burn, Baby Burn) and racism in Alabama between 1965 and 1966.

Justice Moldaver then turns to what is described as practical considerations for law enforcement and the administration of justice, at paras. 183 - 6, suggesting that (a) the disclosure of text messages received by a complainant could be challenged by a sender who is alleged to have abused the complainant and thus exposes vulnerable complainants such as children, people with mental disabilities and the elderly (b) the increased need for warrants could strain police and judicial resources in an overburdened criminal justice system and (c) at the trial stage, these repercussions could complicate and prolong proceedings where defendants have standing to challenge searches conducted against collateral targets in large prosecutions.

Binding arbitration is held either before one arbitrator or a panel of arbitrators in larger cases, such as where a product defect may have been a factor in the car accident, and the process more like a trial with the arbitrators generally retired judges.

Even a very incomplete list gives an impression of the large number of significant opinions he has written: seminal administrative law cases such as Chevron v. NRDC and Massachusetts v. EPA, the intellectual property case Sony Corp v. Universal City Studios (which made clear that making individual videotapes of television programs did not constitute copyright infringement), important war on terror precedents such as Rasul v. Bush and Hamdan v. Rumsfeld, important criminal law cases such as Padilla v. Kentucky (holding that defense counsel must inform the defendant if a guilty plea carries a risk of deportation) and Atkins v. Virginia (which reversed precedent to hold it was unconstitutional to impose capital punishment on the mentally retarded), and of course Apprendi v. New Jersey (which revolutionized criminal sentencing by holding that the Sixth Amendment right to jury trial prohibited judges from enhancing criminal sentences beyond statutory maximums based on facts other than those decided by a jury beyond a reasonable doubt).

He has handled large, complex cases and numerous jury and non-jury trials for clients such as MetLife, Northwestern Mutual, Unum, and Lincoln Financial Group.

Nolet, [2010] S.C.J. No. 24: 48 The discovery of a large sum of cash may not on its own constitute objective, reasonable and probable grounds to arrest for possession of proceeds of crime but the existence of the cash may contribute to such reasonable grounds when «circumstances or evidence... exist that create a reasonable inference that the money is proceeds of crime» (trial judgment, at para. 35): see R. v. Perello, 2005 SKCA 8, 193 C.C.C. (3d) 151; R. v. Franks, 2003 SKCA 70, 176 C.C.C. (3d) 488.

Particularly in the criminal courts such evidence is likely to be crucial in a large proportion of trials, and courts and advocates must be able to deal with the technical issues it presents.

He drove a number of change initiatives, such as Justice on Target (that reduced, for the first time in 18 years, the time to trial and the number of court appearances per criminal case), a health and safety initiative that reduced workplace injuries by 20 % in 3 years, the 4 Pillars of Family Reform, Civil Justice Reform, the largest funding increase in Legal Aid's history, and was part of a new approach to indigenous relations recognized by the United Nations.

If there is ever a dispute over an unpaid auto insurance claim, such as a large personal injury claim or an uninsured motorist claim, the insurance company will probably use this loophole to force you into a costly civil court trial.

Existing SNHV trials show relatively modest effects (effect sizes of 0.2 — 0.4 SDs) for outcomes such as child mental health and behaviour, and cognitive and language development, from infancy to mid - childhood.19 While effect sizes of 0.25 — 0.3 SDs can be meaningful and impactful at the whole of population level, 59 targeted public health interventions such as SNHV include a cost and intensity such that larger effects in the short - to - medium term might be necessary to justify implementation at a population level.

Most trials of prenatal home visiting have produced disappointing effects on pregnancy outcomes such as birth weight and gestational age, 9,16,17 although one program of prenatal and infancy home visiting by nurses has reduced prenatal tobacco use in two trials18, 19 and has reduced pregnancy - induced hypertension in a large sample of African - Americans.20

If successful, such interventions can then constitute the basis for larger indicated prevention trials.