Sentences with phrase «such mechanisms of resistance»

Not exact matches

«Dr. Guo's study has identified a new mechanism of efficiently inhibiting biological processes that are critical to the function of the disease - causing organism, such that resistance is minimized or eliminated.»

Further investigations could pave the way to a more complete understanding of the genetics and metabolomics of cell growth in yeast and the underlying mechanisms relevant to other settings in which cells face challenging conditions, such as cancer progression and the evolution of drug resistance.

The study also may have broader implications for how clinicians approach the development of such treatments and understand mechanisms behind resistance to treatment in other cancers.

First of all, it seems that biodiversity may not offer as much protection if the event in question is very extreme: buffering mechanisms which drive ecosystem resistance, such as compensation by better - adapted species or species taking over the functional role of others (functional redundancy), may simply be overwhelmed in such cases.

Such a strategy will require a better understanding of the molecular mechanisms of antibiotic resistance, so in this study, the researchers solved the crystal structure of the resistance enzyme aminoglycoside phosphotransferase (4)- Ia in complex with the aminoglycoside hygromycin B.

Meanwhile, our team at the Research Center will be picking up and running with an emerging mechanism of such resistance, testing one of two different platforms to see if we can deny senescent cells the ability to shield themselves from NK clearance.

These results show that acquisition of a JAK inhibitor - resistant mutation such as the Y931C in cells dependent on activated JAK2 V617F for growth is a potential mechanism of secondary resistance to JAK inhibitor therapy in MPN patients.

«In our model, stress conditions, such as a genetic variant or insulin resistance or a high - fat diet, lead to increased availability of the tribbles protein by as yet poorly understood mechanisms,» says Dr. Kulkarni, who is also an Assistant Professor of Medicine at Harvard Medical School.

The role of gene regulation in C. auris drug resistance mechanisms and host interactions — such as overexpression of ERG11 and other known fluconazole resistance genes — are currently unknown.

From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.

These results show that acquisition of a JAK inhibitor resistant mutation such as the F958C in cells dependent on activated JAK1 for growth is a potential mechanism of secondary resistance to JAK inhibitor therapy.

Recent spread of artemisinin resistance and emerging piperaquine resistance in Southeast Asia show that artemisinin combination therapy, such as dihydroartemisinin - piperaquine, are losing clinical effectiveness, prompting investigation of drug resistance mechanisms and development of strategies to surmount emerging anti-malarial resistance.

Many mechanisms of MDR have been described, such as the overexpression of MDR1 (also known as P - glycoprotein or ABCB1) or other ATP - dependent transporters that pump drugs out of the cancer cells, amplification of drug - inactivating enzymes, mutations or modifications of drug targets, alterations in DNA repair machinery, and increased resistance to apoptosis (1 — 3).

The main hypothesis includes a stress preconditioning response mechanism, in which it is believed that periods of nutrient deprivation displays a beneficial mild stress that results in molecular adaptive changes in various tissues, which increases the organism's resistance to bigger stressors such as excitotoxic and oxidative injury, including ischemia (33,71).