Sentences with phrase «such tumors in mice»

Not exact matches

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

Unaltered cells created tumors in all seven mice injected with such cells, but when cells missing ALKBH5 were used, they caused tumors in only 43 percent (six out of 14) of mice.

Further, such treatment significantly suppressed tumor growth in mice.

Next - generation NSG models that support human myeloid cell proliferation, such as the NSG - SGM3 mouse, can now provide in vivo conditions that better mimic the natural tumor environment.

This causes genomic instability in developing immune cells and, in the absence of a working tumor suppressor protein such as p53, an aggressive form of lymphoma develops in mice.

Now we want to extend this technology to animal models, such as cancer bearing mice, to verify its practical use in different types of tumors,» explains Park.

Additionally, organizations such as Freiburg - based Oncotest, a company founded and directed by Fiebig, and the Jackson Laboratory in Bar Harbor, Maine, provide access to a wide range of PDX mice made from donated tumor tissue.

To answer basic research questions like these, investigators study bacteria, viruses, fungi, animal cells and human cells (both healthy and cancerous) grown in the lab, and tumors in animals, such as mice and rats.

Higher serum levels of pro-inflammatory factors such as interleukin - 6 and tumor necrosis factor are found in aged mice.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

Similar to the mouse study above, another group looked at skin tumors (squamous cell carcinoma) in a group of mice prone to such cancers, to see if acute stress could modify this.

Administers veterinary staff approved supportive care such as dietary additives, supplemental environmental enrichment for hiding and chewing, heating pads, and subcutaneous fluids to distressed mice and rats in studies perusing new treatments for brain tumors, Parkinson's disease, heart disease, and emphysema and genetic studies charting the development of lung cancer and diabetes.