Bacterial overgrowth occurs when the gastric pH was > 3.8.23 Oro - pharyngeal - like bacteria and fecal - like bacteria are significantly more abundant in patients on PPI therapy than in patients on H2 - antagonists and untreated control subjects.24 Treatment for 2 weeks with PPI reduces gastric acid secretion by 75 % and this was
sufficient to permit bacterial colonization
of the stomach in healthy
volunteers.23 Omeprazole (40 mg / day) for 3 months induced gastric bacterial overgrowth in 10
of 30 patients, compared with 1
of 10 control subjects; however, after only 14 days
of PPI treatment (omeprazole 30 mg / day), the total
number of gastric bacteria had increased to a significant level.25
Either a software company will need to develop a custom product for law or a
sufficient number of dedicated
volunteers will need to develop from scratch or customize an open source alternative, such as Zotero.