Sentences with phrase «suggest alternative targets»

Understanding epigenetic mechanisms and their contribution to the persistence of diabetic complications is critical because it could suggest alternative targets for therapy to halt and reverse complications.

Not exact matches

A technique using anesthesia - containing nanoparticles — drawn to the targeted area of the body by magnets — could one day provide a useful alternative to nerve block for local anesthesia in patients, suggests an experimental study in the April issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

Here, we present experiments using a reconstituted fusion system that suggest a simple model in which the complexin accessory helix forms an alternative four - helix bundle with the target - SNARE near the membrane, preventing the vesicle - SNARE from completing its zippering.

It is likely that a similar mechanism operates during cancer invasion, which suggests a promising alternative in which cancer treatments might work in the future, if therapies can be targeted to limit the tissue fluidity of tumors.

This finding suggests that patients with this subtype may respond better to alternative treatments that target their tumors» unique genetic structure, which is different than most cervical cancers.

Since previous studies had suggested that directly targeting CARM1 activity could result in high toxicity, the Zhang lab searched for an alternative therapeutic approach.

General and targeted (Campaign 911, Project Red Ribbon) awareness efforts, and education programs targeted to youth, to inform about the dangers of impaired driving, suggest alternatives and change impaired driving behaviours.

• Reduced salon energy bills by 50 % by suggesting and implementing an alternative source of energy • Sold salon retail products worth $ 6900 in one day, exceeding sales targets in one day • Scheduled appointments over the phone and oversaw receptionist work to ensure that appropriate follow - up is made • Hired, trained and developed staff • Ensured that staff members were provided with appropriate targets • Liaised with vendors and suppliers • Indulged in suggestive selling in a bid to meet the salon's sales targets

The presentation addresses the empirical foundations of schema theory by shedding light on the role of early maladaptive schemas in depression etiology and reviews the clinical evidence of schema therapy as a possible treatment option for (chronic) depression: Limited evidence suggests that ST by targeting self - referential cognitive schemas (EMS) which mediate the effects of early life adversity on vulnerability towards and maintenance of depressive disorders in the sense of distal risk factors could be an effective treatment for depression and a feasible alternative to CBT (Brewin et al. 2009; Carter et al. 2013; Malogiannis et al. 2014; Renner et al. 2016).