Studies comparing human milk from preterm mothers with that from term mothers
suggest that these immunologic benefits may be even greater for preterm infants because secretory immunoglobulin A (IgA), lysozyme,
lactoferrin, and interferon are found in greater concentrations in preterm human milk compared with term milk.2 — 4 Very low birth weight (VLBW) infants do not benefit from the transplacental transfer of maternal immunoglobulins that occurs primarily after 34 weeks of gestation.5 These infants are exposed to abundant pathogenic organisms during neonatal intensive care unit (NICU) hospitalization and may benefit from the host defense factors present in preterm human milk.6 — 9