This work
suggests early life exposure can cause damage to a person's genome that can be passed down through generations.
Not exact matches
However, increasing evidence has
suggested that
early nutritional
exposures, perhaps in the first weeks of postnatal
life, may also modify cardiovascular risk, including blood cholesterol concentrations, in later
life (8, 9).
But animal studies also
suggest that
early life exposure to some EDCs can cause weight gain later in
life, and, as a result, have been called «obesogens.»
Here's the result that has gotten the most press: Academic research careers were less popular with the late cohorts than the
early ones in all disciplines,
suggesting, perhaps, that graduate students are disillusioned by
exposure to the
lives and careers of their faculty advisers.
While previous studies have established that reducing allergen
exposure in the home helps control established asthma, the new findings
suggest that
exposure to certain allergens
early in
life, before asthma develops, may have a preventive effect.
The findings
suggest that the negative effects of elevated and chronic
exposure to nitrogen dioxide and tiny dirty air particles begin in
early life.
Some epidemiologic evidence
suggests that arsenic
exposure in utero and
early in
life may be associated with adverse effects on fetal growth, and on infant and child immune and neurodevelopment outcomes.
However, interestingly, it also
suggested for the first time that in smokers,
exposure to tobacco
early in
life through passive smoking in childhood significantly increased this risk.
The researchers
suggest that
living in a rural or urban environment may change the intestinal microbiome, due to different
exposures early in
life, resulting in decreased or increased risk
The study, published online today in PLoS Genetics, is the first to
suggest that low, brief
exposures to bisphenol - A, or other estrogens such as those used in birth control but found as water contaminants,
early in
life can alter the stem cells responsible for producing sperm later in
life.
Some evidence also
suggests that arsenic
exposure early in
life can affect a child's immune system and intellectual development, according to the FDA and background notes from the study authors.
An evolving view
suggests that adrenal fatigue is not a glandular problem, but rather a brain - stress problem.52
Early -
life exposure to mercury also causes epigenetic damage to the HPA axis, which can dysregulate the stress response throughout
life.
But the authors write in their paper that «emerging epidemiologic evidence
suggests that [arsenic]
exposure in utero and during
early life may be associated with adverse health effects» on immune system and brain development.
«This is just one of a number of studies
suggesting that there are
exposures early in
life that may determine [breast cancer] risk in adulthood,» says Larissa Korde, MD, a staff clinician at the National Cancer Institute and the lead author of the study in the journal Cancer Epidemiology, Biomarkers and Prevention.
The findings
suggest a significant role of cumulative risk experiences depending on the duration of
exposure to poverty, as well as sensitive periods during
early life.10, 12 The effect of poverty appears to be slightly stronger on verbal than on non-verbal skills, confirming previous findings.50, 51
The importance of
early interventions that target caregiving is underscored by studies demonstrating high cost - effectiveness through greatly enhanced long - term outcomes.41 Furthermore, children who receive more nurturing caregiving may also be protected from
exposure to stressful
life events,
suggesting this central target may have positive ramifications on brain development.42 Considering these issues, study findings are relevant to the public policy debate on the importance of
early preschool programs for young children
living in poverty.
Evidence linking psychological stress to asthma continues to grow with our increased understanding of the natural history of asthma and the neurobiology underlying stress vulnerability.1 - 3 Stress
exposure during infancy and
early childhood may exert particularly robust effects on the physiological systems that respond to stress.4 - 6 Evidence from animal and human studies strongly
suggests that
early life adversity shapes stress neurobiology, 7 resulting in disturbed regulation of endocrine and autonomic processes (eg, hypothalamic - pituitary - adrenal [HPA] axis, sympathetic - adrenal - medullary system).
Studies consistently
suggest that
exposure to trauma or chronic
early life stress may impair the development of executive function skills.6, 7,9,10,11 These skills appear to provide the foundation for school readiness through cognition and behaviour.3, 12 Children with better executive function skills may be more teachable.3 Indeed, in a high - risk sample, children with better executive function skills at the beginning of kindergarten showed greater gains in literacy and numeracy than children with poorer initial skills.12 Considering there is evidence that
Studies consistently
suggest that
exposure to trauma or chronic
early life stress may impair the development of executive function skills.6, 7,9,10,11 These skills appear to provide the foundation for school readiness through cognition and behaviour.3, 12 Children with better executive function skills may be more teachable.3 Indeed, in a high - risk sample, children with better executive function skills at the beginning of kindergarten showed greater gains in literacy and numeracy than children with poorer initial skills.12 Considering there is evidence that the achievement gap persists and may even widen across the school years, 16,17 it is critical that high - risk children begin school with as successful of a start as possible.
A harsh
early environment was associated with an elevated flat cortisol trajectory across the stress tasks,
suggesting that HPA axis functioning may have been compromised by recurring or chronic
early life stress
exposure.
Specifically, there was no evidence to
suggest that the
Early Start group experienced benefits in the areas of maternal health, family functioning, family economic conditions, or
exposure to
life stresses (Table 1).