Sentences with phrase «supernumerary centrosomes»
Remarkably, the short - term presence of cells with supernumerary centrosomes in PLK4OE / p53cKO mice was sufficient to generate aneuploidy in the adult epidermis and triggered spontaneous skin cancers with complete penetrance.
https://science.institut-curie.org/
To tackle this question, we have focused our attention on centrosome amplification, a dysfunction characterized by the presence of supernumerary centrosomes, and initially described as a main feature of cancer only.