Sentences with phrase «support clinical use»

«Further studies to clarify the impact and full effects of mTOR signaling are needed in order to support the clinical use of mTOR inhibitors in patients with spinal cord injury,» the authors wrote.

A first - of - its - kind literature review published in the September issue of Anesthesiology, the official medical journal of the American Society of Anesthesiologists ® (ASA ®), suggests although a majority of studies report positive outcomes, there is currently insufficient evidence to support the clinical use of antidepressants for the treatment of postoperative pain.

(3) Future clinical application of human germline genome editing should not proceed unless, at a minimum, there is (a) a compelling medical rationale, (b) an evidence base that supports its clinical use, (c) an ethical justification, and (d) a transparent public process to solicit and incorporate stakeholder input.

Not exact matches

On Thursday, the company announced it had struck 15 separate trade deals in China, one of the most notable being a partnership with Tencent Holdings to advance the use of artificial intelligence to support research and clinical decision making.

Watson for Oncology, which was developed by IBM in collaboration with Memorial Sloan Kettering Cancer Center (MSK) in New York, will be used as an AI - based clinical decision support solution.

Sun Life will also conduct periodic reviews of the growing body of clinical research supporting the use of medical cannabis for other conditions, and update its criteria if necessary, the company said in a document updating their client base of 22,300 plan sponsors.

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To achieve this goal, several approaches are envisaged: identifying small populations with severe disease where a medicine's benefit - risk balance could be favorable; making more use of real - world data where appropriate to support clinical trial data; and involving health technology assessment bodies early in development to increase the chance that medicines will be recommended for payment and ultimately covered by national healthcare systems.

This includes a stem cell research centre, a network of drug discovery institutes and a # 20 million global clinical development fund dedicated to supporting Phase I and II clinical trials; and a # 2 million collaboration between University of Cambridge and University College London that will use donated cells from people with Alzheimer's to test potential new treatments

«The benefits of probiotics are strain specific, which means formulators need to look at the clinical studies supporting the exact probiotic strain used to determine what benefits to claim, and ensure inclusion rates through the end of shelf life to support these amounts,» Bush says.

«Elecampane has many uses, but its most beautiful quality is how it supports the lungs,» says clinical herbalist Arielle Hayat, who works at Flower Power, one of New York's oldest herb shops.

Giroud does not deserve to lead the arsenal line next season.He should be replaced do u know why?It is because he is always going to miss a lot of chances and will cost us.people who support him to lead the line have not studied his game clearly.every season he will continue to cost us.But at least i wont say he is useless or something.He is on the pitch and gives his all so he is useful.He is not clinical and not good at all.He is a striker who is just above average but sometimes even performs below average in his 3 years over here.Be honest and say it as it is.Some people use stats to constantly defend him yet if you watch him you will be shocked.Walcott can lead the line he has everything to.but as i said he lacks the aggressiveness and physique to be the main man.that will go against him so many times.so its better for him to remain on the wings.Giroud does not deserve it.We all know that.

Although there are currently no published studies to support the use of impact sensor systems in this manner, and a «concussion threshold» is unknown, the potential clinical utility should be carefully considered.

When I chronicled our first grueling night of sleep training two weeks ago, mothers who had successfully used the method developed by Weissbluth, a sleep expert and professor of clinical pediatrics at Northwestern's Feinberg School of Medicine, wrote and offered their support.

Howard et al (2004), surveying 2000 mostly African American 8th grade boys found the vast majority willing to use protection: this resulted in the local hospital restructuring its teen family planning clinical services to give the same in - hospital clinical and counselling support to young males as to young females

In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.

It states that Patient Rescue will use data streams from hospitals to build other tools, in addition to Streams, that could carry out real - time analysis of clinical data and support diagnostic decisions.

In the future, they may use brain imaging to support clinical tests.

«We support careful and sensible use of neuroimaging in which physicians exercise excellent clinical judgment to reduce waste in the medical system,» Dr. Hawasli and coauthors write.

The final results from an international clinical trial involving nearly 2,000 patients with Crohn's disease support the use of a new management strategy referred to as accelerated step - care as a best practice for the care of active Crohn's disease.

Hamburg noted that «I reviewed and thoughtfully considered the data, clinical information, and analysis provided by» FDA's drug experts, «and I agree... that there is adequate and reasonable, well - supported, and science - based evidence that Plan B One - Step is safe and effective and should be approved for nonprescription use for all females of child - bearing potential.»

The same work will enhance the traditional computerized clinical decision support (CDS) systems that medical professionals use — knowledge bases that contain the latest wisdom on therapeutic treatments.

A team from Oxford's Nuffield Department of Clinical Neurosciences, led by Professor Heidi Johansen - Berg and Dr Charlotte Stagg, studied the use of transcranial direct current stimulation (tDCS) to support rehabilitation training.

However, results of the four clinical trials published in the NEJM were used to support the regulatory filing submitted to the FDA by the drug's developer, Gilead Sciences, Inc..

These important new data support the use of joint fluid as a readily available alternative to study the role of these changes in the onset of joint disease and in the clinical management of this condition.

Dr Chris Gale is supported by a Medical Research Council (MRC) Clinician Scientist Fellowship to develop large, simple clinical trials that use routinely recorded electronic health record data held in the National Neonatal Research Database (NNRD).

«Although hypothermia is a promising strategy to improve resuscitation and brain recovery following cardiac arrest, the results of the current study do not support routine use of cold intravenous fluid in the prehospital setting to improve clinical outcomes,» the authors write.

The study, which is published today in the Journal of Clinical Hypertension and is supported by Barts Charity, devised a novel treatment strategy for 55 patients, involving fractional dosing with tablets (halving or quartering pills), liquid formulations of antihypertensive drugs and patch formulations of antihypertensive drugs — plus use of unlicensed drugs that lower blood pressure.

This has previously happened in other fields of health with an automated interpretation of results from an electrocardiogram being routinely used in clinical practice as a decision support system.

Using specimens collected annually in patients seen at Dr. Young's bone marrow failure clinic at the NIH Clinical Center, the investigators show that patients can support good blood cell production for many years from only a few stem cell clones, which can contain many unfavorable mutations.

Lorenz Studer, a stem - cell biologist at the Memorial Sloan Kettering Cancer Center in New York City who has spent years characterizing such neurons ahead of his own planned clinical trials, says that «support is not very strong» for the use of precursor cells.

«The field has really exploded with several devices in clinical practice despite lack of compelling data to support their use.

The white paper recommends that practitioners follow relevant guidance documents and that deviation from consensus recommendations should be supported by clinical studies or pursued in the setting of a clinical trial approved by an institutional review board; that practitioners receive training in a new procedure before beginning its practice, that the training should include a practical, «hands - on» component and that all team members directly involved with the radiation therapy decisions should participate in at least five proctored cases before performing similar procedures independently; and that professional societies should accelerate the generation of new or updated guidance documents for the following disease sites and techniques: skin, central nervous system, gastrointestinal, lung or endobronchial and esophagus, and, while outside the charge of this panel, assess the need for updated guidance documents for accelerated partial breast irradiation using electronic brachytherapy.

This finding supports the negative predictive value of using PET imaging to identify patients unlikely to decline, which has important implications for both clinical research and treatment.

«More efforts, such as clinical decision support, are needed to reduce unnecessary cardiac stress testing,» Dr. Ladapo concludes, suggesting greater use of stress testing without radiological imaging, such as regular exercise treadmill tests or stress testing with ultrasound imaging as opposed to CT imaging.

«When we embarked on this study, early clinical trials and laboratory studies supported the possibility (or hypothesis) that earlier therapy in appropriate patients with docetaxel, used in combination before hormonal resistance occurred, could have greater benefit, but required proof in a definitive study.

Third, they must reference the source of the data using a unique identifier of a clinical trial's data set to provide appropriate credit to those who generated it and allow searching for the studies it has supported.

The findings reveal that the IAT spectrum is expanding rapidly in volume and variety over time, and encompasses intelligent systems supporting various assistive tasks and clinical uses.

Thirdly, the current, almost universal dependency of organoid culture on the use of Matrigel as a replacement for the function of the extracellular basement matrix in providing structural support and survival signals to the epithelial cells hampers clinical application, considering its origin from a mouse sarcoma cell line, its poorly defined composition and its mechanical rigidity after plating.

Although these platforms can be used successfully for small - scale expansion of hMSCs, other platforms will be required to generate the quantity of cells required to support the increasing number of clinical trials utilizing hMSCs and the subsequent large - scale production.

Ultimately, the goal is to deliver more personalized prevention and treatment for a much greater number of women,» said Rebecca Sutphen, M.D., Clinical Geneticist at Moffitt Cancer Center and Advisory Board member at Informed Medical Decisions, Inc., a network of genetic counselors who provide support to physicians and patients using deCODE's tests.

The GDC will support clinical trials that focus on single patients, known as «n of 1» clinical trials, and will become an important component in how precision medicine is used to treat individual patients.

Clinical Diagnostics The platform will provide service and support in order to promote and adapt the use of high throughput techniques, such as next - generation sequencing, microarray - based analyses and multiplex protein analysis, in routine diagnostics.

Seed Money for Translational Pilot Projects Charis Eng, MD, PhD, Chair, Genomic Medicine Institute, advises all faculty that the Cleveland Clinical and Translational Sciences Collaborative (CTSC) and the School of Medicine, Case Western Reserve University, will provide seed money to faculty in multidisciplinary programs for Pilot Projects that will lead to effi cient use of resources and support of inter-institutional, clinical translational research in the City of ClClinical and Translational Sciences Collaborative (CTSC) and the School of Medicine, Case Western Reserve University, will provide seed money to faculty in multidisciplinary programs for Pilot Projects that will lead to effi cient use of resources and support of inter-institutional, clinical translational research in the City of Clclinical translational research in the City of Cleveland.

These criteria exist in order to ensure that the study is conducted in accordance with the scientific principles and integrity maintained by the Vanderbilt - Ingram Cancer Center, that the scientific aims of the study can reasonably be met, and that Cancer Center resources used to support clinical investigation are appropriately and wisely used.

Rehm is also a co-investigator of the BabySeq Project exploring the clinical use of genomic sequencing as an adjunct to newborn screening, principal investigator in the eMERGE consortium supporting genomic discovery and genomic medicine implementation, and a principal investigator on a project to develop i2b2 into a Health Innovation Platform for clinical decision support.

Therefore, this work provides strong support for the use of iPSC ‐ derived MSC as a more uniform with well ‐ defined phenotype and function as a sustainable source of cells which paves the way for a clinical application for IBD cellular therapy.

Both of her clinical labs focus on the rapid translation of new genetic discoveries into clinical tests and bringing novel technologies and software systems into molecular diagnostics to support the integration of genetics into clinical use.

«A number of our assays and associated bioinformatics software are currently being used by leading cancer centers and pharmaceutical partners in support of optimizing treatments for patients, and to stratify, enroll, and track MRD in patients in international phase II and phase III clinical studies.

SAN DIEGO, March 28, 2017 (GLOBE NEWSWIRE)-- Invivoscribe ® Technologies Inc., a global company with decades of experience providing internationally standardized clonality and biomarker testing solutions for the fields of oncology, personalized molecular diagnostics ®, and personalized molecular medicine ®, reports that its next - generation sequencing (NGS) LymphoTrack ® Assay kits are being used by its LabPMM ® clinical laboratories, pharmaceutical partners, and cancer centers to identify and monitor chimeric antigen receptor T - cells (CAR - T) and engineered T - cell receptors in peripheral blood of subjects in support of immuno - therapeutic drug development and treatment regimen development for both hematologic and solid tumors.