hGDAsBMP provided extensive benefit, including robust protection of spinal cord neurons, increased
support of axon growth and locomotor recovery.
Not exact matches
Oligodendrocytes, the cells that are known to produce the myelin sheaths which enable saltatory conduction
of action potentials along the myelinated
axons, are modulators
of signal transmission along neuronal connections (
axons) and also promote neuronal survival by providing metabolic
support.
The team also performed a biochemical screen to identify molecules expressed in scar tissue and discovered relatively high levels
of factors that
support axon growth.
Sheng and his research fellow Bing Zhou, the first author
of the study, initially found that when mature mouse
axons are severed, nearby mitochondria are damaged and become unable to provide sufficient ATP to
support injured nerve regeneration.
This is
supported by post-mortem studies showing a modest loss
of mDA
axons in the striatum 1 year after PD diagnosis, with a complete loss
of mDA striatal innervation in patients 4 years after diagnosis, while some mDA neuronal soma remained [6].
EXPERIENCE: Intern Architect, Garrison McNeil and Associates, Architects and Planners 04.08 - present — Office Managerial Duties: office
support duties, purchasing manager — Marketing: Letters
of Interest; RFQ's; RFP's — Zoning / Building Code Analysis — Site Survey — Development
of schematic and design development phase plans, elevations, sections, and rendered axonometrics — Construction Documents: Fluent in construction document standards and construction details (section and
axon)-- In - house Specification and Project Manual Compilation: proof - reading and writing architectural specifications — Presentation Prep: materials boards, presentation boards