Microglia
support photoreceptors by keeping the connections between them intact.
Similar patches and treatments have already been tested against the «wet» form — in which blood vessels invade and destroy the retinal pigment epithelial cells that nourish and
support the photoreceptor cells that capture light.
The findings from our proposed studies will further define how the RPE
supports the photoreceptor functions via metabolic coupling, and hopefully identify novel druggable targets for preventing RPE and retinal degeneration during AMD.
Not exact matches
Without RPEs to
support and nourish them, adjacent
photoreceptor cells which capture light signals, die too and blindness is the result.
As RPEs help to maintain and
support adjacent
photoreceptor cells which capture light, their loss leads to blindness.
«This is the first time that such an integral membrane protein has been localized in the
photoreceptor cells and shown to have the capacity to
support sight,» notes Dr. Bazan, the paper's corresponding author.
These cells are interdependent, as RPE provides nutritional
support to allow
photoreceptors to respond to light.
The findings
support a path to improving clinical applications, specifically for restoring vision in humans by allowing
photoreceptors derived from human stem cells to integrate and thrive in the eye.
With age, our eyes accumulate waste in retinal pigment epithelium (RPE), which
supports the life and function of
photoreceptors (light sensitive cells in the eye); in advanced stages, RPE and
photoreceptors die.
Behind the
photoreceptors is another layer of cells called retinal pigment epithelium (RPE), which
support the rods and cones by delivering nutrients from the bloodstream and removing waste that the rods and cones generate.
The treatment could help people who have a fault in a gene called RPE65, which causes problems in the retinal pigment epithelium (RPE), a thin layer of cells that
support and nourish
photoreceptors.
It is likely that those cells would then
support the function of the very important
photoreceptor cells in the retina.
These are the
photoreceptor support cells in the retina that are critical for the process of light into sight conversion.