Sentences with phrase «supporting preclinical studies»

In collaboration with the University of Massachusetts Medical School (UMMS) and Auburn University (AU), Lysogene is developing IND - supporting preclinical studies using AAV gene therapy technology to translate the initial proof of concept into a viable drug development program to the benefit of patients in urgent need.

Through the collaboration, Lysogene, UMMS and AU will develop IND - supporting preclinical studies in GM1 - gangliosidosis using AAV gene therapy technology.

The social venture company within the foundation is moving fast on getting the first steps done; however, it won't have enough money to finish the project, and has conducted fundraising campaigns which have helped to support the preclinical studies that are paving the way for the first human trial.

Not exact matches

The new data builds off several preclinical studies supporting the use of ibrutinib with CAR therapy.

Many factors may cause differences between current expectations and actual results including unexpected safety or efficacy data observed during preclinical or clinical studies, clinical trial site activation or enrollment rates that are lower than expected, changes in expected or existing competition, changes in the regulatory environment, failure of Syndax's collaborators to support or advance collaborations or product candidates and unexpected litigation or other disputes.

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

Together our data support the notion that targeting DGKζ, a negative regulator of T cell activation, or other regulators of Erk activation, could be useful in the treatment of human malignancy and that additional preclinical studies of intracellular «brakes» on T cell activation are warranted.

Together with the research and clinical resources of the nation's leading cancer hospital, we have the ability to take a program from a research hypothesis all the way to a clinical candidate supported by robust preclinical data, and into early phase clinical studies in well - defined patient populations.

«The initiation of the NPT088 Phase 1b trial is supported by a substantial preclinical development program and the recent successful completion of a Phase 1a study in healthy volunteers.

These new preclinical studies provide support for advancing the Ad26 / MVA prime - boost vaccine candidate into clinical development.

The Clinical Pharmacology Resource supports investigators in the design, analysis, and interpretation of clinical pharmacology objectives in preclinical and clinical studies, including chemoprevention and epidemiological studies.