Sentences with phrase «suppress cells involved»

Azathioprine is used to suppress cells involved in autoimmune diseases.

Not exact matches

One factor keeping cells in this immature state is the PTEN gene, which suppresses a signalling pathway involved in cell growth.

Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but not normal breast tissue.

The research team found that this non-coding RNA fragment maintains healthy cells through two mechanisms: Firstly by regulating the levels of DIRAS3, one of its neigboring genes that is involved in cell replication; secondly by suppressing a network of genes that prepare cells to change their shape and prepare for metastasis.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

These factors work together to activate genes involved in fashioning heart muscle cells, while suppressing genes characteristic of other cell types.

Children with asthma have lower vitamin A levels than children without asthma, and the degree of vitamin A deficiency they exhibit is directly proportional to the severity of their asthma.37, 38 In cell experiments, vitamin A eliminates the response of bronchial smooth muscle cells to growth factors that characterizes the asthmatic reaction39 and suppresses the activity of mast cells, which are involved in asthmatic or other reactions mediated by histamine or other inflammatory chemical messengers called leukotrienes.40 Consistent with studies in isolated cells, vitamin A deficiency causes asthmatic bronchial hyper - reactivity in live rats.41