Sentences with phrase «suppress tumor»

T α 1 itself has been shown to exhibit antibacterial and antifungal properties, suppress tumor growth, increase vaccine effectiveness, and protect against oxidative damage.

Take - Home Messages If short - term fasting is appropriate, it potentially may be an effective, inexpensive strategy to decrease side effects, suppress tumor progression, protect patients against the effects of chemo - toxicity, and further improve prognosis when used with chemotherapy.

In cancer, it is generally accepted that autophagy can suppress tumor initiation.

Enforced expression of miR - 200c can strongly suppress the tumor formation driven by human BCSCs and the mammary ducts formation by normal mammary stem cells in vivo, suggesting that miR - 200c is a regulator of normal mammary and BCSCs.

Tumor suppressor genes generally suppress tumor growth and control cell growth.

Similarly, antigen - specific CD4 + CD25 + regulatory T cells also suppress tumor - specific CD8 T cell cytotoxicity although this mechanism relies on TGF - β secretion by regulatory cells 196, 197.

Because the proteins can be engineered to suppress tumor growth they have emerged as a potential cancer therapy.

As a result, they can more efficiently interact with the cell membrane, regulate cell growth and suppress tumor formation.

«Vaccine directed against tumor blood vessels suppress tumor growth, metastasis.»

«An important possible advantage to this approach is that these therapeutic T cells have the potential to replicate in the body, and therefore they might suppress tumor growth and prevent relapse for a prolonged period,» Yu says.

miR - 184 is known to suppress tumor development by regulating a variety of genes involved in cancer growth, while SND1 has been shown to play a significant role in the development of breast, colon, prostate and liver cancers.

In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal model.

This is where small molecule therapeutics could be developed to interfere with the signals and suppress tumor growth.

But by combining the drug with a PGAM1 inhibitor to impair both homologous recombination and PARP - dependent DNA repair, the researchers were able to significantly suppress tumor growth.

And these ITCs apparently destroy the products of the mutant p53 gene, but leave the healthy p53 proteins alone and free to suppress tumor development.

Additional experiments also showed that TiY can suppress the tumor growth in mice xenograft model.

We have sought to tip the battle in favor of the brain to suppress the tumor.»

For example, the other milk protein, whey, has been shown to suppress tumor growth, but T. Colin Campbell's research didn't take that into account.

When genes that typically act to suppress tumors are methylated, the tumors metastasize.

The researchers began by investigating a gene called Lgl, which normally suppresses tumor growth.

If the silencing occurred in a gene responsible for suppressing tumor formation, the result would appear the same as genetic mutations that predispose people to cancer.

For example, genes involved in suppressing tumor formation are turned off via epigenetic mechanisms, and genes involved in rapid growth and replication are turned on too high.

«Mus81 really does play a critical role» in suppressing tumors, says Stephen West, a biochemist at Cancer Research UK in London.

The team's recent study in mice has found that the treatment reduced the mass of ovarian cancer tumors and was more effective at suppressing tumor growth than chemotherapy.

Using a robotics - based screening approach, researchers screened a library of 1,192 FDA - approved drugs for any that suppressed tumors in the fly and identified several that improved overall survival.

Further, such treatment significantly suppressed tumor growth in mice.

«Enzyme could protect against type of colorectal cancer by suppressing tumors, study finds.»

«Our system is based around a molecule called E-cadherin, which suppresses tumor growth in part by maintaining cells in an epithelial rather than a mesenchymal state,» Tomoki Muramatsu of TMDU says.

An enzyme that plays an active role in inflammation could be a natural way to suppress tumors and ulcers in the colon that are found in colitis associated cancer (CAC), a type of colorectal cancer that is driven by chronic inflammation, according to a new study.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

Beyond identifying the Sestrin1 gene as frequently altered in FL patients, the scientists demonstrated that Sestrin1 is able to suppress tumors in vivo.

They could still be effective at suppressing tumors, but they might lead to other, unwanted side effects.

In 2005, Cagan's team created a general fly model of a human thyroid tumor caused by mutations in the Ret receptor tyrosine kinase gene, then screened a panel of drugs including a kinase inhibitor called vandetanib that suppressed the tumor (Cancer Res, 65:3538 - 41, 2005).

Two microRNAs with synergistic effects, one that suppresses tumor growth and another than inhibits tumor promotion, are combined in an RNA triple helix, complexed with a dendrimer to form nanoparticles, which are incorporated with a polymer to form a hydrogel that inhibits tumor growth when applied to the tumor.

Paul Ehrlich proposes that the immune system usually suppresses tumor formation, a concept that becomes known as the «immune surveillance» hypothesis.

Huang YY, Dai L, Gaines D, Droz - Rosario R, Lu H, Liu J, Shen Z. BCCIP Suppresses Tumor Initiation but Is Required for Tumor Progression.

On the other hand, the tumors will also reproduce rapidly if genes that suppress tumors are silent.

Alternate reading frame protein (ARF) complexes with mouse double minute 2 homolog 2 (MDM2), an E3 ubiquitin ligase that regulates the stability of p53 and therefore suppressing tumor growth, it is also involved in the immune response, by modulating the tumor environment [46].

TRAIL is a natural antitumor protein that suppresses tumor development during immune surveillance, the immune system's process of patrolling the body for cancer cells.

«The TRAIL pathway is a powerful way to suppress tumors but current approaches have limitations that we have been trying to overcome to unleash an effective and selective cancer therapy,» said Dr. Wafik El - Deiry, professor of medicine and chief of the hematology / oncology division, Penn State College of Medicine.

The ARID1A gene, normally suppresses tumors, and the PPP2R1A gene, is an oncogene that, when altered, helps turn normal cells into tumor cells.

This wonder veggie even has antioxidants and has historically been used to suppress tumors.

The research showed that it suppresses tumor growth and prevent cancer and the carcinogenic substances.

Coffee is the major source of caffeine which has been reported to both stimulate and suppress tumors, depending upon the species and the phase of administration [5].

Tea has been scientifically associated with health benefits such as suppressing tumor progression and decreasing inflammation.

Not exact matches

After EZH2 enzymes rise, their levels taper off, and then, the scientists found two to three-fold increases in a protein called DNMT1, which maintains DNA methylation in the «start» location of a variety of tumor suppressor genes that normally suppress cell growth.

Similarly, when these cells were injected into mice, the cells in which SLC13A5 was suppressed formed barely discernable tumors compared to the unmanipulated cancer cells.

Teixeira and his team also found that a malfunctioning tumor - suppressing gene that's associated with certain cancers, such as colon and pancreatic, and is known as Stk11, additionally influenced the development of BPH.

The findings, which were demonstrated in several major subtypes of melanoma tumors (including BRAF and NRAS melanoma), could lead to drug development strategies that suppress the development of drug resistance.

Northwestern Medicine scientists have identified a small RNA molecule called miR - 182 that can suppress cancer - causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor.