Enforced expression of miR - 200c can strongly
suppress the tumor formation driven by human BCSCs and the mammary ducts formation by normal mammary stem cells in vivo, suggesting that miR - 200c is a regulator of normal mammary and BCSCs.
As a result, they can more efficiently interact with the cell membrane, regulate cell growth and
suppress tumor formation.
If the silencing occurred in a gene responsible for
suppressing tumor formation, the result would appear the same as genetic mutations that predispose people to cancer.
For example, genes involved in
suppressing tumor formation are turned off via epigenetic mechanisms, and genes involved in rapid growth and replication are turned on too high.
Paul Ehrlich proposes that the immune system usually
suppresses tumor formation, a concept that becomes known as the «immune surveillance» hypothesis.
Not exact matches
These TAMs
suppress the immune system and stimulate blood vessel
formation thereby stimulating the growth of the
tumor.
A protein that appears to play a key role in the
formation of lymphoma and other
tumors by inhibiting a
tumor -
suppressing gene has been identified by a team of veterinary and human medicine researchers at the University of California, Davis.