Like the isolated compound, tribulus terrestris inhibited TNF - a and
suppressed the COX - 2 gene.
«Because TIA - 1 is known to
suppress COX - 2 expression in other cells, we reasoned that the inactivation of the TIA - 1 gene would increase COX - 2 expression in neurons and, consequently, would increase resistance to acute seizures,» he continues.
UC - II doesn't work by
suppressing the COX or LOX enzymes, though.
The greens seem to
suppress the COX - 2 enzymes, the same molecules that non-steroidal anti-inflammatory drugs target, according to Leah Hechtman, author of «Clinical Naturopathic Medicine.»
These anti-inflammatories do not
suppress either COX; instead they interfere with the EP4 receptor, a prostaglandin receptor involved in pain generation.
Not exact matches
This suggests that a better understanding of the regulation of
COX - 2 expression in the brain can provide new insights into molecular mechanisms that
suppress seizure - induction,» adds Hewett, a pharmacologist by training.
The gold standard for
suppressing this process would be non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin, naproxen, and ibuprofen, but they tend to target just the
COX enzymes (
COX1 and
COX2).
In addition, bradykinase, a natural pain reliever, is also present, as is aloe emodin, found by researchers to
suppress production of
COX - 2 and nitric oxide — both of which trigger inflammation.
For instance, researchers have found that curcumin from turmeric has the ability to fight damaging free radicals, while
suppressing the inflammatory enzyme
COX - 2.