Sentences with phrase «suppressive cells in the tumor»
Given its potential ability to block the function of immune suppressive cells in the tumor microenvironment, entinostat is also being evaluated in combination with approved PD - 1 antagonists.
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However, tolerance - inducing mechanisms and the presence of suppressive cell types in the tumor microenvironment can dampen the response to immunotherapy.
Recently, there has been progress in the treatment of patients with malignancy through targeting receptors on the surface of CD8 + T cells that inhibit their activity within the highly suppressive tumor microenvironment.
Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.
Through a genetic screen in Drosophila, Igaki identified the ligand Sas and the receptor - type tyrosine phosphatase PTP10D as the cell - surface ligand - receptor system that drives tumor - suppressive cell competition.
A great deal of evidence has now been amassed that stromal cell senescence plays an important role in laying the groundwork for tumor metastasis, promoting cell proliferation with inflammatory cytokines, encouraging angiogenesis, and degrading the tumor - suppressive action of an intact extracellular matrix.
iTeos focuses upon selected key suppressive mechanisms of immunity in cancer based on gene expression, association with immune cell subsets, protein expression in human tumors and biological validation.
At the same time, we retain a strong commitment to investigating the cancer cell itself, finding new opportunities in targeting in oncogenic and tumor suppressive pathways, as well as in next - generation antibody - drug conjugates.