Sentences with phrase «suppressor activity»
Researchers at Penn State College of Medicine, working with Chinese and American colleagues, have discovered a novel way to enhance and restore cancer suppressor activity in B - cell acute lymphoblastic leukemia, resulting in better outcomes in a pre-clinical model of the disease.
https://pennstatehealthnews.org/
It was hypothesized that BAP1 tumor suppressor activity could reside, at least in part, in stabilizing proteins through its poly - deubiquitinase activity.
Further, the group found that the 2b proteins of the related viruses all have the suppressor activity even though they share limited sequence similarities.
In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activity.
Not exact matches
The researchers further found that miR - 486 is itself regulated by the tumor - suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.
A quantitative assay of the suppressor tRNA activity in these mammalian cells is described; it is based on the amount of tRNA - mediated readthrough of a terminating codon in the influenza virus NS1 gene after the cells are infected with virus.
«Even though Foxo1 is a tumor suppressor gene, paradoxically its activity is associated with lymphomas,» said Kurosaki.
«We found polyploidy in liver cells did not strongly affect the activity of some oncogenes, but it did protect against the loss of tumor suppressor genes.
His research activities currently focus on identifying metastasis suppressor genes in colorectal cancer.
«A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1»
LKB1, originally identified as a tumor suppressor protein, is currently thought as a critical regulator of cellular metabolism and growth by controlling the activity of AMP - activated protein kinase (AMPK) and also 12 other kinases that are closely related to AMPK.
Dr. Almog received a Ph.D. from the Weizmann Institute of Science, Israel, where she was studying the molecular mechanisms regulating the activity of the tumor suppressor protein p53.
To analyze whether overexpressing either GBP1 or GBP2 is sufficient to rescue the effect of reduced TOR activity in the fat body, we co-overexpressed suppressors of TOR signaling, TSC1 and TSC2, and either GBP1 or GBP2 in the fat body.
This approach would inactivate the DAXX pathway for tumor promotion, and consequently restore the activity of the DAPK1 and DAPK3 tumor suppressors.
â $ œTaken together, our results suggest that MBD2 overexpression during gliomagenesis may drive tumor growth by suppressing the anti-angiogenic activity of a key tumor suppressor.
These suppressor genes are inactivated in tumors, and since cancer drugs work by reducing the activity of enzymes, they won't work on such suppressors because a drug can't inhibit a gene that is already inactivated.»