Sentences with phrase «suppressor by»

MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype - associated genes in medulloblastoma.

On the other hand, aberrant expression of miR - 7 was observed in glioblastomas, and it has been characterized as a putative tumor suppressor by targeting EGFR and AKT (23, 24).

Not exact matches

The integral suppressor seal has a one - piece design to provide a seal against compression leakage and improve the spark plug's lifespan by metering energy.

Furthermore, the team found that ONA inhibited the pro-tumor functions of myeloid derived suppressor cells (MDSC), which are closely associated with the suppression of the anti-tumor immune response of host lymphocytes, by using preclinical sarcoma model.

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

Using a genome - wide genetic screen, Dr. Gelman and colleagues identified a previously unknown metastasis suppressor — the FOXO4 protein, which belongs to a family of genes that are produced by all human cells.

Onion A increases anti-tumor immune response by inhibiting the immune suppression actions of macrophage and myeloid derived suppressor cells (MDSC).

Working with colleagues at St. Vincent's Hospital in Sydney, Martin identified two individuals who had the characteristics of hereditary nonpolyposis colorectal cancer, which is usually caused by a mutation that inactivates one of a person's two copies of the tumor suppressor gene MLH1, but who showed no signs of mutation.

Finding drugs that reactivate the tumour suppressor protein p16 silenced by methylation would also be a boon.

Now, in a provocative study that raises unsettling questions about the widespread use of vitamin supplements, Swedish researchers have showed that relatively low doses of antioxidants spur the growth of early lung tumors in cancer - prone mice, perhaps by hindering a well - known tumor suppressor gene.

Along with finding that the tumor suppressor protein SIRT6 is inactive in around 30 percent of cases of pancreatic ductal adenocarcinoma (PDAC), the team identified the precise pathway by which SIRT6 suppresses PDAC development, a mechanism different from the way it suppresses colorectal cancer.

A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor genes are silenced — occurs in adult brains and can be triggered by environmental cues.

In their research on young mice, for instance, all the subjects died when they were infected with the Nodamura virus, but when Ding's researchers removed the suppressor protein called B2 from the virus, the infected mice began producing huge armies of the virus - attacking siRNAs and lived, unaffected by the otherwise lethal infection.

A study published in Molecular Cancer Research reveals that a tumor suppressor gene p16 is turned off by a histone mutation (H3.3 K27M), which is found in up to 70 percent of childhood brain tumors called diffuse intrinsic pontine glioma (DIPG).

A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

The researchers further found that miR - 486 is itself regulated by the tumor - suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.

The tumor suppressor p53 does all it can to prevent oncogenes from transforming normal cells into tumor cells by killing defective cells or causing them to become inactive.

This paracrine effect was brought about by the tumor suppressor Par - 4, which specifically kills cancer cells.

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.

RUNX3 is a tumour suppressor gene that prevents the formation of tumours by binding to DNA.

These effects are partly mediated by tumor suppressor p53, which is frequently mutated in human cancers.

After the KRAS mutation was induced by the researchers, other mutations in what are known as tumor suppressor genes developed.

A significant finding by the team was that either the mutant KRAS gene or another cancer gene is amplified, depending on which tumor suppressor gene is affected and to what degree its function is impaired.

«This function for BAI1 may have implications for cancer biology, since MDM2 can function as an oncogene by degrading important tumor suppressors like p53.»

Now, results of a new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful role for the protein in normal breast cells, acting as a tumor suppressor that halts abnormal cell growth.

The scientists are planning further study of HOXA5's role in breast cancer, following up on this work and a study published by Sukumar's lab in 2000 that showed a connection between low levels of HOXA5 and the well - known tumor suppressor protein p53.

About three - fourths of renal cell carcinoma cases are marked by a missing VHL tumor - suppressor gene, which keeps healthy cells from developing into tumors.

Since 1971, the standard tumor suppressor model has held that cancer is caused by a «two - hit» cascade in which first one copy and then the second copy of a gene becomes mutated.

In this study, published in the journal Cell Reports, and led by Dr. Esteban Ballestar (IDIBELL), the comparison of the epigenetic profiles between dendritic cells and myeloid - derived suppressor cells has allowed them to identify the existence of specific epigenetic alterations that associated with the development of myeloid - derived suppressor cells as a result of exposure to prostaglandin E2.

Dr. Shawn Li, PhD, and his team at Western's Schulich School of Medicine & Dentistry, identified that a protein called Numb functions to promote the death of cancer cells by binding to and stabilizing a tumor suppressor protein called p53 - a master regulator of cell death.

Importantly, about 70 percent of LFS families have a mutation in their version of the gene TP53, which is the blueprint for protein p53, well known by the nickname «the tumor suppressor.»

In fact, KLF4 blocks senescence and apoptosis by repressing transcription of P53, whereas it can activate P21 - dependent cell - cycle arrest, and therefore, KLF4 can function both as a tumor suppressor and an oncogene (33, 34).

Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in BRCA1 / 2 - mutated tumors.

It has been known for a number of years that PREX2 is a GTP / GDP exchange factor that inhibits a tumor suppressor protein called PTEN, and that this process can promote tumorigenesis by activating the PI3K signaling pathway (Fine et al., 2009; Hodakoski et al., 2014; Figure 1A).

In breast cancer, miR - 7 was shown to block invasiveness and tumorigenic potential by targeting PAK, which is consistent with the idea of tumor suppressor function of miR - 7 (25).

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.

Exchange protein activated by cyclic AMP (Epac)- mediated induction of suppressor of cytokine signaling 3 (SOCS - 3) in vascular endothelial cells.

Inactivation of the tumor suppressor gene RASSF1A by promoter hypermethylation represents a key event underlying the initiation and progression of lung cancer.

The product of the p53 tumor suppressor gene is discovered independently by several groups: Lionel Crawford and David Lane; Albert Deleo and Lloyd Old; and Arnold Levine.

We demonstrate that the alpha2 beta1 integrin is a metastasis suppressor of breast cancer and we identify key mechanistic steps in the metastatic cascade enhanced by loss of alpha2 beta1 integrin expression.

Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the tumor suppressor gene p53 that is commonly mutated in human prostate cancers.

TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP - 1.

These results suggest that MSC mediate allogeneic tolerance by directing APC towards a suppressor or inhibitory phenotype that results in an attenuated or regulatory T cell response.

The suppression of LCMV - specific CTL responses by carrier spleen cells is not mediated by a suppressor cell, but is due to the presence of genetic variants of LCMV in spleens of carrier mice.

LKB1, originally identified as a tumor suppressor protein, is currently thought as a critical regulator of cellular metabolism and growth by controlling the activity of AMP - activated protein kinase (AMPK) and also 12 other kinases that are closely related to AMPK.

This is unusual for a tumor suppressor: most will reduce life span by inhibiting regeneration and tissue maintenance at higher levels.

Identification of Suppressors of mbk - 2 / DYRK by Whole - Genome Sequencing.

P53: The protein p53 plays the role of tumor suppressor, but creating a general increase in p53 levels will, in addition to reducing cancer incidence, also accelerate aging by reducing tissue maintenance through the creation of new cells.

This is also shown by Beyth et al 117 who suggest that human MSC converted APC into an inhibitory or suppressor phenotype via cell - to - cell contact, thus locking DC into a semi-mature state and thereby inducing peripheral tolerance.