Sentences with phrase «suppressor called»

LA JOLLA, CA — A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells.

LA JOLLA, CA — A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc...

The drug, lapatinib, activates the suppressor called FOXO, in HER2 + breast cancer cells, but then FOXO becomes a turncoat molecule, working with an epigenetic regulator that controls gene expression.

Razqallah Hakem, a cancer biologist at the University of Toronto in Ontario, and his colleagues normally study a tumor suppressor called BRCA1, variants of which put women at high risk of breast and ovarian cancer.

For a variety of male mammals, vasectomy (sometimes reversible) and castration are the most common contraceptive methods, though there has been success in some species with hormone suppressors called GnRH agonists.

Not exact matches

Since the gene product of YME1 is a potent suppressor of mitochondrial DNA migration into the genome of the yeast Saccharomyces cerevisiae, Tiwari and Singh investigated the human homologue of the YME1 gene, called YME1L1.

After EZH2 enzymes rise, their levels taper off, and then, the scientists found two to three-fold increases in a protein called DNMT1, which maintains DNA methylation in the «start» location of a variety of tumor suppressor genes that normally suppress cell growth.

Up to 90 % of colorectal tumors contain inactivating mutations in a tumor suppressor gene called adenomatous polyposis coli (Apc).

In their research on young mice, for instance, all the subjects died when they were infected with the Nodamura virus, but when Ding's researchers removed the suppressor protein called B2 from the virus, the infected mice began producing huge armies of the virus - attacking siRNAs and lived, unaffected by the otherwise lethal infection.

But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.

A study published in Molecular Cancer Research reveals that a tumor suppressor gene p16 is turned off by a histone mutation (H3.3 K27M), which is found in up to 70 percent of childhood brain tumors called diffuse intrinsic pontine glioma (DIPG).

The investigators also discovered that a potent suppressor of autophagy (called mTOR) was hyperactivated in the kidneys of obese mice, and treatment with an mTOR inhibitor ameliorated autophagy insufficiency.

The researchers first used yeast to quickly and cheaply screen 169,000 interactions between yeast versions of human tumor - suppressor genes and genes that can be inhibited with drugs, sometimes called «druggable» targets.

Among them: some genes believed to be tumor suppressors turned on or became more active, whereas certain disease - promoting ones, including oncogenes (in the so - called RAS family that are implicated in both prostate and breast cancer), were down - regulated or switched off.

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

One of those downregulated genes encodes a tumor suppressor protein called p21.

For example, they produce proteins called cytokines that tell infection - fighting immune cells to back off and recruit «suppressor» cells directly from the bone marrow that help cancel the immune attack.

In a retrospective case study involving published data on p53, an important tumor suppressor protein, the team showed that this new resource called the Knowledge Integration Toolkit (KnIT) is an important first step in that direction, accurately predicting the existence of proteins that modify p53 — proteins that were subsequently found to do just that.

The puzzle pieces should come together once we understand a special group of patients called elite suppressors, the one - in - 300 HIV - positive adults with turbocharged immune systems capable of hunting and killing HIV.

The cells, called myeloid - derived suppressor cells (MDSCs), are found abundantly in the microenvironment around tumors.

Dr. Shawn Li, PhD, and his team at Western's Schulich School of Medicine & Dentistry, identified that a protein called Numb functions to promote the death of cancer cells by binding to and stabilizing a tumor suppressor protein called p53 - a master regulator of cell death.

Looking at recent genomic data, Pandolfi and colleagues noticed that another tumor suppressor gene, called PML, tended to be present in localized (non-metastatic) prostate tumors, but was absent in about a third of metastatic prostate tumors.

It has been known for a number of years that PREX2 is a GTP / GDP exchange factor that inhibits a tumor suppressor protein called PTEN, and that this process can promote tumorigenesis by activating the PI3K signaling pathway (Fine et al., 2009; Hodakoski et al., 2014; Figure 1A).

«Through further functional studies we found that myosin IIa is also required for activation of the main guardian of the genome — a tumor suppressor protein called p53.»

When these genes (called tumor suppressor genes) are turned off, MDS cells and cancer cells can grow freely.

8/7/2008 Researchers Discover How Tumor Suppressor Inhibits Cell Growth Genes that inhibit the spontaneous development of cancer are called tumor suppresSuppressor Inhibits Cell Growth Genes that inhibit the spontaneous development of cancer are called tumor suppressorsuppressor genes.

Cold Spring Harbor, NY — The gene called PTEN is one of the most important of the body's natural tumor suppressors.

Wilms» tumor is a childhood kidney cancer caused by the loss or inactivation of a tumor suppressor gene called QT1 on chromosome 11.

Romidepsin (Istodax) and vorinostat (Zolinza) inhibit enzymes called histone deacetylases (HDACs) that tighten the coil around DNA and block expression of tumor suppressor genes.

Van Meirâ $ ™ s laboratory has been studying a tumor suppressor protein called BAI1 (brain angiogenesis inhibitor 1), which prevents tumor and blood vessel growth.

One of these escape mechanisms involves a type of immune cell called myeloid - derived suppressor cells (MDSCs).