Sentences with phrase «suppressor cells induced»

Not exact matches

One type of cell, the polymorphonuclear myeloid - derived suppressor cell (PMN - MDSC), was present exclusively in the induced tumors.

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.

Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the tumor suppressor gene p53 that is commonly mutated in human prostate cancers.

The tumor suppressor p53 is critical in the protection of cells against radiation - induced carcinogenesis, most likely through its ability to trigger apoptosis of radiation - damaged cells (45).

This is also shown by Beyth et al 117 who suggest that human MSC converted APC into an inhibitory or suppressor phenotype via cell - to - cell contact, thus locking DC into a semi-mature state and thereby inducing peripheral tolerance.

Many, if not all, oncogenes and tumor suppressor genes induce metabolic reprogramming in cancer cells through changes in the regulation of enzymes and transporters.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

His lab has made contributions in the area of tumor induced immunosuppression of dendritic cells, characterization of human myeloid derived suppressor cells, and the development of novel adjuvants for cancer vaccines.

When introduced into the MDA - MB - 231 cells, the Δ2A mutant did not induce apoptosis of these cells whereas WT LARP7 readily impaired cell survival, supporting the model that the ability of LARP7 to assemble 7SK snRNP and suppress P - TEFb is necessary for its tumor suppressor potential.