Sentences with phrase «suppressor gene associated»
Both mutations affect the function of CDKN2A, a tumor suppressor gene associated with melanoma in humans.
http://www.scilifelab.se/ Not exact matches
«It wasn't known whether miR - 486 functioned as an oncogene or a tumor - suppressor gene in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Program.
«Even though Foxo1 is a tumor suppressor gene, paradoxically its activity is associated with lymphomas,» said Kurosaki.
Analysis of genomic, epigenetic, and RNA sequencing data revealed that the combinations of mutations that lowered the levels of functioning BRCA1 and BRCA2 RNA — genes that produce the breast cancer tumor suppressor proteins — were associated with significantly better survival outcomes.
MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype - associated genes in medulloblastoma.
Dr. Eng and team create scoring system to facilitate identifying individuals to be referred to PTEN gene testing Researchers have discovered a method for more precise identification of individuals who should undergo testing for genetic mutations of the tumor suppressor gene PTEN, which associates with a variety of conditions including several types of cancers.
Covering a combination of oncogenes and tumor suppressor genes, this panel is designed to cover some of the most commonly mutated genes associate with AML.
DAXX associates with RelB, a transcription factor of the NF - κB family that directly controls the expression of numerous apoptosis - and autophagy - relevant genes, including tumor suppressor protein kinases DAPK1 / 3 [1; 2].
Of these, 126 genes were orthologous to protein - coding genes in the human genome (hereafter, human BC susceptibility genes, hBCSGs), 70 % of which are previously reported cancer - associated genes, and ∼ 16 % are known BC suppressor genes.