We have found that the initiation of pancreatic cancer does not follow the classic paradigm seen in colon cancer where loss of a tumor
suppressor gene initiates tumorigenesis and then acquisition of an oncogene promotes tumor formation.
Not exact matches
And in at least a few lab - reared fish, UV can
initiate the development of melanoma (especially among hybrids which inherit a tumor - promoting
gene from one parent but no accompanying tumor -
suppressor gene from the other).
These complexes lead to mutations in the TP53 tumor
suppressor gene, which in turn
initiate the process toward kidney cancer.