Not exact matches
However, the impact of the two methylation -
regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of
genes — many of which are key tumor
suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.
The researchers further found that miR - 486 is itself
regulated by the tumor -
suppressor gene p53, the most frequently altered
gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.
Among them: some
genes believed to be tumor
suppressors turned on or became more active, whereas certain disease - promoting ones, including oncogenes (in the so - called RAS family that are implicated in both prostate and breast cancer), were down -
regulated or switched off.
P53 is a tumor
suppressor gene, a protein that
regulates cell growth, and it is the most frequently mutated
suppressor gene in cancer.
Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are
regulated by the tumor
suppressor gene p53 that is commonly mutated in human prostate cancers.
Mutations in one of these
genes, NF1 — a known tumor
suppressor gene that
regulates the RTK / RAS / RAF pathway — had previously been reported in lung cancer.
Metastasis suppression: the evolving role of metastasis
suppressor genes for
regulating cancer cell growth at the secondary site.
Conjugated linoleic acid (CLA) up -
regulates the estrogen -
regulated cancer
suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells.
The virus activates growth - promoting
genes in the DNA (oncogenes), at the same time it inactivates
suppressor genes that would normally limit cell proliferation and alters the
genes that
regulate normal, programmed cell death.