Sentences with phrase «suppressor genes based»
They generated a list of suspected oncogenes and tumor suppressor genes based on their mutation patterns — and found many more potential cancer drivers than anticipated.
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A quantitative assay of the suppressor tRNA activity in these mammalian cells is described; it is based on the amount of tRNA - mediated readthrough of a terminating codon in the influenza virus NS1 gene after the cells are infected with virus.
Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in BRCA1 / 2 - mutated tumors.