Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor
suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»
Some examples from their lab include using AAV to introduce epitope tags into the endogenous alleles of the p53 and PTEN tumor
suppressor genes in human cells (Kim et al 2008).
Not exact matches
Spalax naturally have a variant
in the p53
gene (a transcription factor and known tumor
suppressor), which is identical to a cancer - related mutation
in humans, Band said.
After working on the genetics of yeasts during a Ph.D.
in pharmacy at the University of Valencia, Gil moved to the United States for a postdoc on
human suppressor genes.
The researchers further found that miR - 486 is itself regulated by the tumor -
suppressor gene p53, the most frequently altered
gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.
They tested these drugs one at a time for lethal interaction with 112 different tumor -
suppressor gene mutations
in human cancer cells growing
in the lab.
All the fish had the
human cancer mutation BRAFV600E — found
in most benign moles — and had also lost the tumor
suppressor gene p53.
This phenomenon could result
in breakage
in the
human genome, and when a breakage impacts important
genes, such as tumor
suppressors, it could lead to cancer development.
In humans, cancer develops when
genes that suppress cancer, known as tumor
suppressors, are lost and when mutations or
genes that promote cancer, known as oncogenes, are gained or activated.
They have also used AAV
gene editing to introduce naturally occurring cancer - causing mutations into the endogenous allele of the STAG2 tumor
suppressor in human cells -LRB-
They have also used AAV
gene editing to introduce naturally occurring cancer - causing mutations into the endogenous allele of the STAG2 tumor
suppressor in human cells (Kim et al, 2016).
Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the tumor
suppressor gene p53 that is commonly mutated
in human prostate cancers.
Moreover, many
human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating
in the early steps of the transformation cascade
in inherited cancers caused by heterozygous mutation
in tumor
suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??
Cyanidin increased SIRT6 enzyme levels
in human colorectal cancer cells, and it was also discovered to decrease the expression of the Twist1 and GLUT1 cancer
genes, while increasing the expression of the tumor
suppressor FoXO3
gene in cells.
These tumor
suppressor genes are two of the most frequently altered
genes in human cancer, and understanding how they function at the molecular level will both refine our fundamental understanding of this disease and suggest novel therapeutic approaches to treat it.
Both mutations affect the function of CDKN2A, a tumor
suppressor gene associated with melanoma
in humans.
Senoo M, Tsuchiya I, Matsumura Y, Mori T, Saito Y, Kato H, Okamoto T, Habu S. Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET
gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant - negative isoform, and loss of expression of the potential tumour
suppressor p51.
Of these, 126
genes were orthologous to protein - coding
genes in the
human genome (hereafter,
human BC susceptibility
genes, hBCSGs), 70 % of which are previously reported cancer - associated
genes, and ∼ 16 % are known BC
suppressor genes.
The most frequent tumors
in human — cancer of the colon, breast, lung, and prostate — all involve mutations
in tumor
suppressor genes.
Conjugated linoleic acid (CLA) up - regulates the estrogen - regulated cancer
suppressor gene, protein tyrosine phosphatase gamma (PTPgama),
in human breast cells.