Sentences with phrase «suppressor in human cells»

They have also used AAV gene editing to introduce naturally occurring cancer - causing mutations into the endogenous allele of the STAG2 tumor suppressor in human cells (Kim et al, 2016).

They have also used AAV gene editing to introduce naturally occurring cancer - causing mutations into the endogenous allele of the STAG2 tumor suppressor in human cells -LRB-

Not exact matches

They tested these drugs one at a time for lethal interaction with 112 different tumor - suppressor gene mutations in human cancer cells growing in the lab.

Some examples from their lab include using AAV to introduce epitope tags into the endogenous alleles of the p53 and PTEN tumor suppressor genes in human cells (Kim et al 2008).

Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the tumor suppressor gene p53 that is commonly mutated in human prostate cancers.

Cyanidin increased SIRT6 enzyme levels in human colorectal cancer cells, and it was also discovered to decrease the expression of the Twist1 and GLUT1 cancer genes, while increasing the expression of the tumor suppressor FoXO3 gene in cells.

Senescence has been implicated in the aging process and may function as a tumor suppressor mechanism in human cells.

His lab has made contributions in the area of tumor induced immunosuppression of dendritic cells, characterization of human myeloid derived suppressor cells, and the development of novel adjuvants for cancer vaccines.

Senoo M, Tsuchiya I, Matsumura Y, Mori T, Saito Y, Kato H, Okamoto T, Habu S. Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant - negative isoform, and loss of expression of the potential tumour suppressor p51.

Conjugated linoleic acid (CLA) up - regulates the estrogen - regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells.