Sentences with phrase «suppressor in lung cancer»

The current discovery that MAX acts as a tumor suppressor in lung cancer provides evidence that an aberrant SWI / SNF - MYC / MAX network is essential for lung cancer development.

«MicroRNA molecule found to be potent tumor - suppressor in lung cancer.»

Not exact matches

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

Now, in a provocative study that raises unsettling questions about the widespread use of vitamin supplements, Swedish researchers have showed that relatively low doses of antioxidants spur the growth of early lung tumors in cancer - prone mice, perhaps by hindering a well - known tumor suppressor gene.

The study, «The nuclear transport receptor Importin - 11 is a tumor suppressor that maintains PTEN protein,» which will be published online February 13 in The Journal of Cell Biology, suggests that the loss of Importin - 11 may destabilize PTEN, leading to the development of lung, prostate, and other cancers.

Their finding — that the presence of high levels of NF - κB in lung cancer tumors can act as a suppressor — provides new insight into how tumor pathways regulate the anti-tumor response.

«It wasn't known whether miR - 486 functioned as an oncogene or a tumor - suppressor gene in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Prcancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics PrCancer Genetics Program.

New research shows that microRNA - 486 is a potent tumor - suppressor molecule in lung cancer, and that the it helps regulate the proliferation and migration of lung - cancer cells, and the induction of programmed cell death, or apoptosis, in those cells.

«These findings show that miR - 486 serves a tumor - suppressor function in lung cancer, and that miR - 486 action is partially dependent on p53.»

The article, titled «Entinostat Neutralizes Myeloid Derived Suppressor Cells and Enhances the Antitumor Effect of PD - 1 Inhibition in Murine Models of Lung and Renal Cell Carcinoma,» was published in Clinical Cancer Research and is available online.

«Inactive tumor suppressor gene discovered in lung cancer.»

These findings show that MAX acts as a tumor suppressor gene in one of the more aggressive types of lung cancer.

In nonneuronal tissue, SEMA3B has been postulated to be a tumor suppressor gene of lung and breast cancer.

Mutations in one of these genes, NF1 — a known tumor suppressor gene that regulates the RTK / RAS / RAF pathway — had previously been reported in lung cancer.

The most frequent tumors in human — cancer of the colon, breast, lung, and prostate — all involve mutations in tumor suppressor genes.

«The genotoxicity of mainstream smoke carcinogens manifests as mutations occurring in key cancer - related genes, i.e., proto - oncogenes or tumor suppressor genes that control crucial cellular functions, e.g., growth and survival, in lung tumors of active smokers.»