Sentences with phrase «suppressor mechanism»

On the one hand, autophagy functions as a tumor suppressor mechanism by preventing the accumulation of damaged organelles and aggregated proteins.

Senescence has been implicated in the aging process and may function as a tumor suppressor mechanism in human cells.

It is widely believed that cellular senescence is a tumor suppressor mechanism; however, it has not been understood why it is advantageous for organisms to retain mutant cells is a postmitotic state rather than simply eliminating them by apoptosis.

Not exact matches

Researchers at A * STAR's Singapore Immunology Network (SIgN) have discovered a new mechanism involving p53, the famous tumour suppressor, to fight against aggressive cancers.

Along with finding that the tumor suppressor protein SIRT6 is inactive in around 30 percent of cases of pancreatic ductal adenocarcinoma (PDAC), the team identified the precise pathway by which SIRT6 suppresses PDAC development, a mechanism different from the way it suppresses colorectal cancer.

«These findings reveal a unique fulvestrant signaling process involving the increased regulation of hsa - miR - 765 that suppresses the HMGA1 protein as part of the mechanism underlying the tumor suppressor action in prostate cancer.

This study aimed to determine whether epithelial - derived MMP9 has a defensive role of tumor suppressor in CAC and the underlying molecular mechanism.

This prompted us to characterize in more detail shared mechanisms and pathways and to target them with genetic and pharmacologic means so as to identify some broadly efficient suppressors of muscle degeneration.

Dr. Almog received a Ph.D. from the Weizmann Institute of Science, Israel, where she was studying the molecular mechanisms regulating the activity of the tumor suppressor protein p53.

His growth - regulation research is now focused primarily on the DLC family of tumor suppressor genes and their mechanism of action.

Combining genetics, live - imaging, laser ablation and computer simulations, we aim to analyze whether distinct or similar mechanisms can account for the common role of tumor suppressors and proto - oncogenes in cell - cell contact regulation.

The central focus of my future work is to elucidate the mechanisms by which tumorigenesis results in the conversion of TGFβ from a suppressor of tumor formation to a promoter of tumor growth, invasion, and metastasis.

All CM members have research interests in basic cancer mechanisms, including the normal functions of oncogenes and tumor suppressor genes; regulators of cell cycle and apoptosis; regulators of angiogenesis and metastasis; and stem cells and blood formation.

In a new study published today in the journal Nature Communications, a research team from the Department of Pharmacology and Therapeutics at Roswell Park Cancer Institute reports their discovery of a major mechanism by which cells regulate this important and multifunctional tumor suppressor, opening up new avenues for cancer research and treatment.

One of these escape mechanisms involves a type of immune cell called myeloid - derived suppressor cells (MDSCs).

For example, if both Th1 and Th2 are high and T - suppressor cells are low it indicates that the body is currently defending an attack against antigen, which is preventing the autoimmune mechanism from being efficient in its deactivation.

To figure out the mechanism by which apple peels cleaned cancer's clock, the researchers measured the effect of apple peels on the tumor suppressor protein maspin inside the cancer cells.