Sentences with phrase «suppressor pathway»

Therefore, Numb controls both an oncogenic pathway (the Numb: Notch axis) and a tumour suppressor pathway (the Numb: p53 axis).

Together, our data highlight mechanical roles for proto - oncogene and tumor suppressor pathways in cell - cell interactions.

Not exact matches

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

Along with finding that the tumor suppressor protein SIRT6 is inactive in around 30 percent of cases of pancreatic ductal adenocarcinoma (PDAC), the team identified the precise pathway by which SIRT6 suppresses PDAC development, a mechanism different from the way it suppresses colorectal cancer.

Their finding — that the presence of high levels of NF - κB in lung cancer tumors can act as a suppressor — provides new insight into how tumor pathways regulate the anti-tumor response.

It has been known for a number of years that PREX2 is a GTP / GDP exchange factor that inhibits a tumor suppressor protein called PTEN, and that this process can promote tumorigenesis by activating the PI3K signaling pathway (Fine et al., 2009; Hodakoski et al., 2014; Figure 1A).

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.

Smad4 - dependent suppressor pituitary homeobox 2 promotes PPP2R2A - mediated inhibition of Akt pathway in pancreatic cancer.

SIKE is an IKKε / TBK1 - associated suppressor of TLR3 - and virus - triggered IRF - 3 activation pathways.

Moreover, large - scale screens in the C. elegans DMD model allowed identifying genetic and pharmacologic suppressors of dystrophin - dependent muscle degeneration; some of them positively impact mitochondrial functions or structure under stress conditions, or are involved in signaling pathways linked to mitochondria, and others are associated to proteostasis pathways such as autophagy, proteasome and Unfolded Protein Response (UPR).

The tumor - suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK / Rho signaling pathways.

Subpopulations of myeloid - derived suppressor cells impair T cell responses through independent nitric oxide - related pathways.

This prompted us to characterize in more detail shared mechanisms and pathways and to target them with genetic and pharmacologic means so as to identify some broadly efficient suppressors of muscle degeneration.

He also conducts research that focuses on the GITR and OX40 pathways, as well as how some immune cells, known as myeloid - derived suppressor cells, influence anti-tumor immune responses.

This approach would inactivate the DAXX pathway for tumor promotion, and consequently restore the activity of the DAPK1 and DAPK3 tumor suppressors.

Mutations in one of these genes, NF1 — a known tumor suppressor gene that regulates the RTK / RAS / RAF pathway — had previously been reported in lung cancer.

Amplification of the JAK2 locus has been described in Hodgkin disease and mediastinal B - cell lymphoma, 18,19 and biallelic inactivating mutations in suppressor of cytokine signaling - 1 (SOCS - 1), a negative regulator of JAK2, have been identified in mediastinal B - cell lymphoma.20 Genomic analysis of JAK2 and of other JAK - STAT pathway members may lead to the identification of mutations of the JAK - STAT pathway in lymphoid diseases and other malignancies.

Genetic testing to look at detoxification pathways, tumor suppressor genes, defects to metabolic pathways that may «feed» cancer cells, and more.