These data confirm that LARP7 protein levels are also reduced during breast cancer progression, and thus suggest that LARP7 may play a potential tumor
suppressor role in breast cancer.
But it has proven difficult to collect the firm evidence needed to confirm the tumor -
suppressor role.
Effector and
suppressor roles for LFA - 1 during the development of experimental autoimmune encephalomyelitis.
Not exact matches
In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the
role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor
suppressor activity.
Correspondingly, a large number of genes with no direct
role in tumor progression also are deleted as a result of their proximity to tumor
suppressor genes.
Activation of these receptors led to a «massive mobilisation» of myeloid - derived
suppressor cells (MDSCs), which play a crucial
role in lowering the immune system response back down to normal levels (European Journal of Immunology, DOI: 10.1002 / eji.201040667).
In a previous study, his team worked with other collaborators to identify the potential
role of extra copies of the tumor
suppressor gene (p53) that increase the elephant's ability to eliminate pre-cancerous cells with DNA damage.
Sweatt speculates that H2A.Z plays a
role in modulating memory, serving as a sort of memory
suppressor in cases of unpleasant or painful memories.
«This is the best example that NF1 is a tumor
suppressor,» says David Viskochil, a geneticist at the University of Utah, although he cautions that the case is not yet closed: There still could be other genes that play a
role in NF tumor development.
«Also, because Notch is known to be a tumor
suppressor, the essential
role of Rumi in Notch activation suggests that Rumi could be a tumor -
suppressor as well.
This study aimed to determine whether epithelial - derived MMP9 has a defensive
role of tumor
suppressor in CAC and the underlying molecular mechanism.
Now, results of a new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful
role for the protein in normal breast cells, acting as a tumor
suppressor that halts abnormal cell growth.
The scientists are planning further study of HOXA5's
role in breast cancer, following up on this work and a study published by Sukumar's lab in 2000 that showed a connection between low levels of HOXA5 and the well - known tumor
suppressor protein p53.
«Preclinical results support entinostat's
role in targeting the tumor microenvironment: Entinostat inhibits function of myeloid derived
suppressor cells resulting in enhanced antitumor effect in murine models of lung and renal cell carcinoma.»
The tumor
suppressor gene PTEN is known to play a major
role in prostate cancer; its partial loss occurs in up to 70 percent of primary prostate tumors.
Applying their technique to head and neck cancers, they've discovered seven new tumor -
suppressor genes whose
role in cancer was previously unknown.
Finally, Dr. Goldenring's laboratory is also investigating the
role of Rab25 as a tumor
suppressor in the colon using the Rab25 - / -; Smad3 + / - mouse model, which develops spontaneous invasive distal colon cancers.
Richard K. Gershon and K. (Kazunari) Kondo demonstrate a
role of T cells,
suppressor T cells, in the induction of immunological tolerance.
P53: The protein p53 plays the
role of tumor
suppressor, but creating a general increase in p53 levels will, in addition to reducing cancer incidence, also accelerate aging by reducing tissue maintenance through the creation of new cells.
IL - 10 has a well - documented
role in T cell regulation and in the promotion of a «regulatory» or
suppressor phenotype.
Specifically, Dr. Ramos studied the
role of
Suppressor of Hairy wing [Su (Hw)-RSB- at the global Drosophila level.
She chose the dynamics and function of the tumor
suppressor protein p53, which plays a key
role in cancer and is widely studied.
We have appreciated for some time the causes of this uncontrolled proliferation, in particular the
roles of proto - oncogenes, tumor
suppressors, and their protein products.
These two histones thus have a key
role of epigenetic silencing of tumor
suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.
One may compare the
roles of proto - oncogenes and tumor
suppressors to the accelerator and brake pedal of a vehicle, respectively.
And in view of PTEN's critical
role as a tumor
suppressor, it's also important that the process we uncovered is a controlled one, not random as was previously believed.»
Together, our data highlight mechanical
roles for proto - oncogene and tumor
suppressor pathways in cell - cell interactions.
Tumor
suppressors and proto - oncogenes play crucial
roles in tissue proliferation.
BRCA2 tumour
suppressor protein has a recognized
role in the repair of DNA double strand breaks by homologous recombination.
Combining genetics, live - imaging, laser ablation and computer simulations, we aim to analyze whether distinct or similar mechanisms can account for the common
role of tumor
suppressors and proto - oncogenes in cell - cell contact regulation.
Johnson and Cole Labs uncover a new
role for a tumor
suppressor in DNA repair (11/15/16) Work from the Johnson lab previously showed that E2F1, a critical transcription factor target of the retinoblastoma (Rb) tumor
suppressor protein, localizes to sites of both UV and IR induced DNA damage in a phosphorylation dependent manner.
Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor
suppressor genes in human cancer: the
roles of DNA hypermethylation and the histone code.»
In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor
suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central
role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].
Metastasis suppression: the evolving
role of metastasis
suppressor genes for regulating cancer cell growth at the secondary site.
9) Thu KL, Radulovich N, Becker - Santos DD, Pikor LA, Pusic A, Lockwood WW, Lam WL, Tsao MS. SOX15 is a candidate tumor
suppressor in pancreatic cancer with a potential
role in Wnt / β - catenin signaling.
The
role of histone codes and DNA methylation in silencing tumor
suppressor genes, Cancer Cell 3:89 - 95, 2003.
In essence, Knudson, far ahead of his time (and ahead of his own hard data) hypothesized that some genes» normal
role in life is to behave as anticancer or tumor -
suppressor genes that keep cell division under healthy control.
A
role of HUWE1 has been very controversial in the context of cancer biology — some studies report HUWE1 as a tumor
suppressor, while other studies show HUWE1 as having the potential to cause cancer.
Citing again from the study previously mentioned titled Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll - Like Receptor - 4 and
Suppressor of Cytokine Signaling - 3 «Thus, saturated fats may have a more profound
role in the pathogenesis of postprandial inflammation, as they may also perpetuate inflammation through the increases in LPS and TLR - 4.»
In immune - mediated lacrimal disease, the balance between T -
suppressor and T - helper cells plays an important
role in lacrimal gland regulation.
A disruption in Middle East oil supplies, combined with a robust upturn in global economic growth, could quickly transform oil's
role as an inflation
suppressor into an inflation accelerator.